Cancer is one of the leading causes of death in the United States along with heart disease.
The hallmark of cancer treatment has been conventional chemotherapy. Chemotherapeutic …

Angiogenesis is a critical step in the progression of almost all human malignancies and
some other life-threatening diseases. Anti-angiogenic therapy is a novel and effective …

Abstract Background N6-Methyladenosine (m6A) modification has been implicated in
multiple processes for colon cancer development. IGF2BP3 was a newly reported m6A …

The immature and dysfunctional vascular network within solid tumors poses a substantial
obstacle to immunotherapy because it creates a hypoxic tumor microenvironment that …

Colorectal cancer (CRC) is one the greatest contributors to cancer related mortality.
Although 5 year survival rate for patients at the early stage of CRC (stages I and II) is above …

Angiogenesis, a critical driver of tumor development, is controlled by interconnected
signaling pathways. Vascular endothelial growth factor receptor (VEGFR) 2 and tyrosine …

Angiogenesis—the process of new blood-vessel growth—has an essential role in
development, reproduction and repair. However, pathological angiogenesis occurs not only …

Canine mammary tumors (CMTs) are the most common neoplasm in intact female dogs.
Canine mammary cancer (CMC) represents 50% of CMTs, and besides surgery, which is the …

Protein kinases have grown over the past few years as a crucial target for different cancer
types. With the multifactorial nature of cancer, and the fast development of drug resistance …

Vascular endothelial cells are ordinarily quiescent in adult humans and divide less than
once per decade. When tumors reach a size of about 0.2–2.0 mm in diameter, they become …