In mammals, maternal-to-zygotic transition (MZT), or oocyte-to-embryo transition, begins with
oocyte meiotic resumption due to the sequential translational activation and destabilization …

RNA-binding proteins (RBPs) are key regulators of posttranscriptional gene expression and
control many important biological processes including cell proliferation, development, and …

Meiotic resumption‐coupled degradation of maternal transcripts occurs during oocyte
maturation in the absence of mRNA transcription. The CCR 4–NOT complex has been …

Background Thousands of years of natural and artificial selection have resulted in
indigenous cattle breeds that are well-adapted to the environmental challenges of their local …

Maternal effect genes (MEGs) encode factors (eg, RNA) that are present in the oocyte and
required for early embryonic development. Hence, while these genes and gene products are …

The oocyte faces a particular challenge in terms of gene regulation. When oocytes resume
meiosis at the end of the growth phase and prior to ovulation, the condensed chromatin state …

Vertebrate oocytes face a particular challenge concerning the regulation of gene expression
during meiotic maturation. Global transcription becomes quiescent in fully grown oocytes …

Global transcriptional silencing is a highly conserved mechanism central to the oocyte-to-
embryo transition. We report the unexpected discovery that global transcriptional silencing in …

Regarding to critical roles of oogenesis in formation of ova or unfertilized eggs from the
oogonia by mitotic division and subsequent differentiation, the identification of oogenesis …

RNA-binding proteins are important modulators of mRNA stability, a crucial process that
determines the ultimate cellular levels of mRNAs and their encoded proteins. The …