Antifungal drug resistance: an emergent health threat

A Vitiello, F Ferrara, M Boccellino, A Ponzo, C Cimmino… - Biomedicines, 2023 - mdpi.com
Fungal infections, named mycosis, can cause severe invasive and systemic diseases that
can even lead to death. In recent years, epidemiological data have recorded an increase in …

Perspective on the origin, resistance, and spread of the emerging human fungal pathogen Candida auris

C Sharma, D Kadosh - PLoS Pathogens, 2023 - journals.plos.org
Candida auris is a major emerging human fungal pathogen that was first reported in 2009 as
an isolate from the ear canal of a patient in Japan [1]. Since this initial report, C. auris has …

Increasing Number of Cases Due to Candida auris in North Italy, July 2019–December 2022

C Sticchi, R Raso, L Ferrara, E Vecchi… - Journal of Clinical …, 2023 - mdpi.com
Candida auris is an emerging fungus that represents a serious health threat globally. In Italy,
the first case was detected in July 2019. Then, one case was reported to the Ministry of …

[HTML][HTML] Antifungal therapy of Candida biofilms: Past, present and future

OH Ajetunmobi, H Badali, JA Romo, G Ramage… - Biofilm, 2023 - Elsevier
Virtually all Candida species linked to clinical candidiasis are capable of forming highly
resistant biofilms on different types of surfaces, which poses an additional significant threat …

Recent developments in membrane targeting antifungal agents to mitigate antifungal resistance

D Mehta, V Saini, A Bajaj - RSC Medicinal Chemistry, 2023 - pubs.rsc.org
Fungal infections cause severe and life-threatening complications especially in
immunocompromised individuals. Antifungals targeting cellular machinery and cell …

[HTML][HTML] Mining the nanotube-forming Bacillus amyloliquefaciens MR14M3 genome for determining anti-Candida auris and anti-Candida albicans potential by …

JF Borgio, R Alhujaily, R Alquwaie… - Computational and …, 2023 - Elsevier
There is a global health concern associated with the emergence of the multidrug-resistant
(MDR) fungus Candida auris, which has significant mortality rates. Finding innovative and …

In vitro combination of antifungal drugs with tacrolimus (FK506) holds promise against clinical Candida species, including Candida auris

S Khodavaisy, SA Gharehbolagh… - Medical …, 2023 - academic.oup.com
In vitro interactions between tacrolimus, a calcineurin inhibitor, and fluconazole,
itraconazole, caspofungin, or anidulafungin were evaluated against Candida auris, C …

Uniqueness of Candida auris cell wall in morphogenesis, virulence, resistance, and immune evasion

S Dakalbab, R Hamdy, P Holigová, EJ Abuzaid… - Microbiological …, 2024 - Elsevier
Candida auris has drawn global attention due to its alarming multidrug resistance and the
emergence of pan resistant strains. C. auris poses a significant risk in nosocomial …

The Potential of Dutasteride for Treating Multidrug-Resistant Candida auris Infection

JF Borgio, NB Almandil, P Selvaraj, JS John… - Pharmaceutics, 2024 - mdpi.com
Novel antifungal drugs are urgently needed to treat candidiasis caused by the emerging
fungal multidrug-resistant pathogen Candida auris. In this study, the most cost-effective drug …

Advancements in nanoparticle-based therapies for multidrug-resistant candidiasis infections: a comprehensive review

A Izadi, F Paknia, M Roostaee, SAA Mousavi… - …, 2024 - iopscience.iop.org
Candida auris, a rapidly emerging multidrug-resistant fungal pathogen, poses a global
health threat, with cases reported in over 47 countries. Conventional detection methods …