Skeletal muscle possesses a remarkable regenerative capacity that relies on the activity of
muscle stem cells, also known as satellite cells. The presence of non-myogenic cells also …

Skeletal muscle is composed of a large and heterogeneous assortment of cell populations
that interact with each other to maintain muscle homeostasis and orchestrate regeneration …

Histone deacetylases (HDACs) are part of a vast family of enzymes that have crucial roles in
numerous biological processes, largely through their repressive influence on transcription …

Striated muscle is a highly plastic and regenerative organ that regulates body movement,
temperature, and metabolism—all the functions needed for an individual's health and well …

Protein lysine deacetylases have a pivotal role in numerous biological processes and can
be divided into the Rpd3/Hda1 and sirtuin families, each having members in diverse …

Histone deacetylase inhibitors (HDACi) comprise structurally diverse compounds that are a
group of targeted anticancer agents. The first of these new HDACi, vorinostat …

Skeletal muscle comprises 30–40% of the weight of a healthy human body and is required
for voluntary movements in humans. Mature skeletal muscle is formed by multinuclear cells …

Muscle performance is influenced by turnover of contractile proteins. Production of new
myofibrils and degradation of existing proteins is a delicate balance, which, depending on …

Protein S-nitrosylation constitutes a large part of the ubiquitous influence of nitric oxide on
cellular signal transduction and accumulating evidence indicates important roles for S …

The balance between protein acetylation and deacetylation controls several physiological
and pathological cellular processes, and the enzymes involved in the maintenance of this …