qRT-PCR (real-time reverse transcription-PCR) has become the benchmark for the detection
and quantification of RNA targets and is being utilized increasingly in novel clinical …

An international basis for comparison of BCR-ABL mRNA levels is required for the common
interpretation of data derived from individual laboratories. This will aid clinical decisions for …

The unique molecular characteristic of chronic myeloid leukemia (CML), the disease-
causing ABL (9q34) to BCR (22q11) translocation, has provided an invaluable tool for …

Although the infusion of umbilical cord blood (UCB) from multiple donors can be a strategy
to overcome the cell dose limitation frequently encountered in UCB transplantation, clinical …

Bone marrow examination has become increasingly important for the diagnosis and
treatment of hematologic and other illnesses. Morphologic evaluation of the bone marrow …

In situ hybridization (ISH) is a type of hybridization that uses a labeled complementary DNA
or RNA strand to localize a specific DNA or RNA sequence on a chromosome or section of …

Background Although, molecular genetic analyses became more and more important to
guide therapy decisions in leukemia, banding cytogenetic analysis has retained its vital role …

Introduction BCR-ABL1, resulting from t (9; 22), is the oncogenic driver of chronic myeloid
leukemia and the therapeutic target of the disease. Molecular studies have been the gold …

Abstract Background: For Philadelphia chromosome positive (Ph+) leukemias (chronic
myelogenous leukemia [CML], acute lymphoblastic leukemia [ALL], and rare other …

Objective: The objective of this study was to evaluate the kinetics of molecular response in
chronic myeloid leukemia (CML) patients treated with imatinib and to compare between the …