The ascending serotonin (5-HT) neurons innervate the cerebral cortex, hippocampus,
septum and amygdala, all representing brain regions associated with various domains of …

The study of 5-hydroxytryptamine (5-HT) system has benefited from the identification,
classification and cloning of multiple 5-HT receptors (5-HT1 to 5-HT7). Growing evidence …

The dentate gyrus continues to produce new granule neurons well into adulthood. This has
been demonstrated for many mammalian species, from rodents to primates. The proliferation …

Habituation to a novel environment in rodents is commonly defined as a change in
exploratory or locomotor activity over time (intrasession) or with repeated exposures …

With aging there is a decline in the number of newly generated neurons in the dentate gyrus
of the hippocampus. In rodents and tree shrews, this age-related decrease in neurogenesis …

The production of new neurons declines during adulthood and persists, although at very low
levels, in the aged hippocampus. Since neurogenesis in young adults has been related to …

The perirhinal cortex is located in a pivotal position to influence the flow of information into
and out of the hippocampal formation. In this review, we examine the anatomical …

Aging can be defined as the condition where stressors are not counteracted by protective
functions, leading to a dysregulation in development. These changes can be translated into …

One of the characteristic neuropathological hallmarks of Alzheimer's disease (AD) is the
extracellular accumulation of fl-amyloid peptides (Afl) in neuritic plaques. Experimental data …

Age affects time-dependent respiratory responses to episodic hypoxia in male rats,
particularly long-term facilitation (LTF), a serotonin-dependent respiratory “memory”[Zabka …