Single-cell and spatial transcriptomic technologies have revealed an underappreciated
heterogeneity of liver macrophages. This has led us to rethink the involvement of …

RNA therapeutics show a significant breakthrough for the treatment of otherwise incurable
diseases and genetic disorders by regulating disease-related gene expression. The …

Fibrosis, or tissue scarring, develops as a pathological deviation from the physiological
wound healing response and can occur in various organs such as the heart, lung, liver …

Nanomaterials (NMs) are widely used in commercial and medical products, such as
cosmetics, vaccines, and drug carriers. Exposure to NMs via various routes such as dermal …

The liver is an organ that is particularly exposed to reactive oxygen species (ROS), which
not only arise during metabolic functions but also during the biotransformation of …

The prevalence of liver cancer is constantly rising, with increasing incidence and mortality in
Europe and the USA in recent decades. Among the different subtypes of liver cancers …

The formation of an occlusive thrombus in the blood vessel is the main culprit for numerous
life-threatening cardiovascular diseases that represent the leading cause of morbidity and …

While oral desensitization is capable of alleviating peanut allergen anaphylaxis, long-term
immune tolerance is the sought-after goal. We developed a liver-targeting lipid nanoparticle …

Background & aims In advanced chronic liver disease (ACLD), deregulated hepatic
necroinflammatory processes play a key role in the development of liver microvascular …

Vessel co-option has been demonstrated to mediate colorectal cancer liver metastasis
(CRCLM) resistance to antiangiogenic therapy. The current mechanisms underlying vessel …