An overview of gene regulation in bacteria by small RNAs derived from mRNA 3′ ends

F Ponath, J Hör, J Vogel - FEMS microbiology reviews, 2022 - academic.oup.com
Over the past two decades, small noncoding RNAs (sRNAs) that regulate mRNAs by short
base pairing have gone from a curiosity to a major class of post-transcriptional regulators in …

Specific and Global RNA Regulators in Pseudomonas aeruginosa

P Pusic, E Sonnleitner, U Bläsi - International Journal of Molecular …, 2021 - mdpi.com
Pseudomonas aeruginosa (Pae) is an opportunistic pathogen showing a high intrinsic
resistance to a wide variety of antibiotics. It causes nosocomial infections that are particularly …

Phage proteins target and co-opt host ribosomes immediately upon infection

M Gerovac, K Chihara, L Wicke, B Böttcher… - Nature …, 2024 - nature.com
Bacteriophages must seize control of the host gene expression machinery to replicate. To
bypass bacterial anti-phage defence systems, this host takeover occurs immediately upon …

Integrated Omics Reveal Time-Resolved Insights into T4 Phage Infection of E. coli on Proteome and Transcriptome Levels

M Wolfram-Schauerte, N Pozhydaieva, M Viering… - Viruses, 2022 - mdpi.com
Bacteriophages are highly abundant viruses of bacteria. The major role of phages in
shaping bacterial communities and their emerging medical potential as antibacterial agents …

Grad-seq identifies KhpB as a global RNA-binding protein in Clostridioides difficile that regulates toxin production

V Lamm-Schmidt, M Fuchs, J Sulzer, M Gerovac… - …, 2021 - academic.oup.com
Much of our current knowledge about cellular RNA–protein complexes in bacteria is derived
from analyses in gram-negative model organisms, with the discovery of RNA-binding …

Global profiling of the RNA and protein complexes of Escherichia coli by size exclusion chromatography followed by RNA sequencing and mass spectrometry (SEC …

K Chihara, M Gerovac, J Hörb, J Vogel - RNA, 2023 - rnajournal.cshlp.org
New methods for the global identification of RNA–protein interactions have led to greater
recognition of the abundance and importance of RNA-binding proteins (RBPs) in bacteria …

[HTML][HTML] Exploring the transcriptional landscape of phage–host interactions using novel high-throughput approaches

L Putzeys, L Wicke, A Brandão, M Boon… - Current Opinion in …, 2024 - Elsevier
In the last decade, powerful high-throughput sequencing approaches have emerged to
analyse microbial transcriptomes at a global scale. However, to date, applications of these …

The intricate organizational strategy of nucleus-forming phages

A Prichard, J Pogliano - Current Opinion in Microbiology, 2024 - Elsevier
Nucleus-forming phages (chimalliviruses) encode numerous genes responsible for creating
intricate structures for viral replication. Research on this newly appreciated family of phages …

The world of stable ribonucleoproteins and its mapping with Grad-seq and related approaches

M Gerovac, J Vogel, A Smirnov - Frontiers in Molecular Biosciences, 2021 - frontiersin.org
Macromolecular complexes of proteins and RNAs are essential building blocks of cells.
These stable supramolecular particles can be viewed as minimal biochemical units whose …

In vivo targets of Salmonella FinO include a FinP-like small RNA controlling copy number of a cohabitating plasmid

Y El Mouali, M Gerovac, R Mineikaitė… - Nucleic acids …, 2021 - academic.oup.com
FinO-domain proteins represent an emerging family of RNA-binding proteins (RBPs) with
diverse roles in bacterial post-transcriptional control and physiology. They exhibit an …