[HTML][HTML] Genetics and epigenetics of primary Sjögren syndrome: implications for future therapies

GE Thorlacius, A Björk… - Nature Reviews …, 2023 - nature.com
In primary Sjögren syndrome (pSS), chronic inflammation of exocrine glands results in tissue
destruction and sicca symptoms, primarily of the mouth and eyes. Fatigue, arthralgia and …

Hepatitis B virus mRNA-mediated miR-122 inhibition upregulates PTTG1-binding protein, which promotes hepatocellular carcinoma tumor growth and cell invasion

C Li, Y Wang, S Wang, B Wu, J Hao, H Fan… - Journal of …, 2013 - Am Soc Microbiol
As the most abundant liver-specific microRNA, miR-122 is involved in diverse aspects of
hepatic function and neoplastic transformation. Our previous study showed that miR-122 …

Bisphenol A promotes breast cancer cell proliferation by driving miR-381-3p-PTTG1-dependent cell cycle progression

P Deng, M Tan, W Zhou, C Chen, Y Xi, P Gao, Q Ma… - Chemosphere, 2021 - Elsevier
Bisphenol A (BPA) is a high-production-volume industrial chemical that facilitates the
development of breast cancer. However, the molecular mechanism associated with BPA …

Genetic association of miRNA-146a with systemic lupus erythematosus in Europeans through decreased expression of the gene

SE Löfgren, J Frostegård, L Truedsson… - Genes & …, 2012 - nature.com
A recent genome-wide association study revealed a variant (rs2431697) in an intergenic
region, between the pituitary tumor-transforming 1 (PTTG1) and microRNA (miR-146a) …

[HTML][HTML] Expression and function of the novel proto-oncogene PBF in thyroid cancer: a new target for augmenting radioiodine uptake

VE Smith, JA Franklyn… - Journal of …, 2011 - joe.bioscientifica.com
A method of heterotopic uterine transplantation was developed in the mouse as a model
system for studies of uterine function and transplant immunology of the uterus. The model …

miR-106a-5p carried by tumor-derived extracellular vesicles promotes the invasion and metastasis of ovarian cancer by targeting KLF6

Y Zheng, K Zhu, G Wang - Clinical & Experimental Metastasis, 2022 - Springer
Tumor-derived extracellular vesicles (EVs) promote ovarian cancer (OC) metastasis by
carrying microRNAs (miRs). This study investigated the mechanism of miR-106a-5p carried …

[HTML][HTML] Overexpressed hPTTG1 promotes breast cancer cell invasion and metastasis by regulating GEF-H1/RhoA signalling

YC Liao, JW Ruan, I Lua, MH Li, WL Chen, JRY Wang… - Oncogene, 2012 - nature.com
Human pituitary tumour-transforming gene 1 (hPTTG1) is an oncogenic transcription factor
that is overexpressed in many tumour types, especially tumours with metastatic abilities …

[HTML][HTML] Simvastatin suppresses human breast cancer cell invasion by decreasing the expression of pituitary tumor-transforming gene 1

L Yin, Z He, B Yi, L Xue, J Sun - Frontiers in pharmacology, 2020 - frontiersin.org
Statins, or 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors, have been widely
used to lower cholesterol and prevent cardiovascular diseases. Recent preclinical and …

Somatic complex I disruptive mitochondrial DNA mutations are modifiers of tumorigenesis that correlate with low genomic instability in pituitary adenomas

I Kurelac, A MacKay, MBK Lambros… - Human molecular …, 2013 - academic.oup.com
Mitochondrial DNA (mtDNA) mutations leading to the disruption of respiratory complex I (CI)
have been shown to exhibit anti-tumorigenic effects, at variance with those impairing only …

[HTML][HTML] FoxM1 transactivates PTTG1 and promotes colorectal cancer cell migration and invasion

Y Zheng, J Guo, J Zhou, J Lu, Q Chen, C Zhang… - BMC medical …, 2015 - Springer
Background Metastasis is the major cause of cancer-related death. Forkhead Box M1
(FoxM1) is a master regulator of tumor metastasis. This study aims to identify new FoxM1 …