Multiple phenotype modeling in gene-mapping studies of quantitative traits: power advantages
DB Allison, B Thiel, PS Jean, RC Elston… - The American Journal of …, 1998 - cell.com
Genomewide searches for loci influencing complex human traits and diseases such as
diabetes, hypertension, and obesity are often plagued by low power and interpretive …
diabetes, hypertension, and obesity are often plagued by low power and interpretive …
Review and evaluation of methods correcting for population stratification with a focus on underlying statistical principles
HK Tiwari, J Barnholtz-Sloan, N Wineinger… - Human …, 2008 - karger.com
When two or more populations have been separated by geographic or cultural boundaries
for many generations, drift, spontaneous mutations, differential selection pressures and …
for many generations, drift, spontaneous mutations, differential selection pressures and …
Plasma HDL cholesterol, triglycerides, and adiposity: a quantitative genetic test of the conjoint trait hypothesis in the San Antonio Family Heart Study
MC Mahaney, J Blangero, AG Comuzzie… - Circulation, 1995 - Am Heart Assoc
Background The conjoint trait hypothesis proposes that combined low HDL cholesterol (HDL-
C) and high triglyceride (TG) levels represent a single, inherited phenotype that adiposity …
C) and high triglyceride (TG) levels represent a single, inherited phenotype that adiposity …
New MspI polymorphism at +83 bp of the human apolipoprotein al gene: Association with increased circulating high density lipoprotein cholesterol levels
XL Wang, R Badenhop, KE Humphrey… - Genetic …, 1996 - Wiley Online Library
We recently showed that loss of a MspI restriction site in the 5′‐end (intron 1) of the
apolipoprotein (apo) AI gene is due to a C to T transition (+ 83 bp) and/or a G to A transition …
apolipoprotein (apo) AI gene is due to a C to T transition (+ 83 bp) and/or a G to A transition …
Polymorphisms at the 5'-end of the apolipoprotein AI gene and severity of coronary artery disease.
XL Wang, SX Liu, RM McCredie… - The Journal of clinical …, 1996 - Am Soc Clin Investig
Elevated HDL-cholesterol (C) and apo AI are associated with decreased coronary artery
disease (CAD) risk. We determined distributions of two MspI polymorphisms of the apo AI …
disease (CAD) risk. We determined distributions of two MspI polymorphisms of the apo AI …
Apolipoprotein A1 gene polymorphisms and risk of early coronary disease
JR Reguero, GI Cubero, A Batalla, V Alvarez, S Hevia… - Cardiology, 1998 - karger.com
Genetic studies have identified polymorphisms at the apolipoprotein (Apo) A1 gene
associated with HDL cholesterol and apolipoprotein levels, and a relationship between the …
associated with HDL cholesterol and apolipoprotein levels, and a relationship between the …
Pleiotropy and genotype by diet interaction in a baboon model for atherosclerosis: a multivariate quantitative genetic analysis of HDL subfractions in two dietary …
We investigated dietary effects on pleiotropic relationships among 3 HDL cholesterol (C)
subfractions (HDL1-C, HDL2-C, and HDL3-C; levels quantified by gradient gel …
subfractions (HDL1-C, HDL2-C, and HDL3-C; levels quantified by gradient gel …
The effect on transcription efficiency of the apolipoprotein AI gene of DNA variants at the 5′ untranslated region
XL Wang, RB Badenhop, AS Sim… - International Journal of …, 1998 - Springer
Elevated circulating levels of high-density lipoprotein and apolipoprotein AI are associated
with reduced coronary artery disease risk. We have shown that a C to T substitution at+ 83 …
with reduced coronary artery disease risk. We have shown that a C to T substitution at+ 83 …
Segregation analysis of abdominal visceral fat: the HERITAGE Family Study
T Rice, JP Despres, L Perusse, J Gagnon… - Obesity …, 1997 - Wiley Online Library
Abstract RICE, TREVA, JP DESPRÉS, LOUIS PÉRUSSE, JACQUES GAGNON, ARTHUR S
LEON, JAMES S SKINNER, JACK H WILMORE, DC RAO, CLAUDE BOUCHARD …
LEON, JAMES S SKINNER, JACK H WILMORE, DC RAO, CLAUDE BOUCHARD …
Segregation analysis of apolipoproteins A-1 and B-100 measured before and after an exercise training program: the HERITAGE Family Study
P An, T Rice, J Gagnon, IB Borecki… - … , and vascular biology, 2000 - Am Heart Assoc
Complex segregation analyses of apolipoproteins (apo) A-1 and B-100 were performed in a
sample of 520 individuals from 99 white families who participated in the HERITAGE Family …
sample of 520 individuals from 99 white families who participated in the HERITAGE Family …