Perspectives on the treatment of malignant pleural mesothelioma

SM Janes, D Alrifai, DA Fennell - New England Journal of …, 2021 - Mass Medical Soc
Mesothelioma Most mesotheliomas originate in the pleura and are due to asbestos
exposure. The incidence is decreasing somewhat with asbestos remediation, but mortality …

Inhibition of FGF‐FGFR and VEGF‐VEGFR signalling in cancer treatment

G Liu, T Chen, Z Ding, Y Wang, Y Wei, X Wei - Cell proliferation, 2021 - Wiley Online Library
The sites of targeted therapy are limited and need to be expanded. The FGF‐FGFR
signalling plays pivotal roles in the oncogenic process, and FGF/FGFR inhibitors are a …

[HTML][HTML] Malignant pleural mesothelioma: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up☆

S Popat, P Baas, C Faivre-Finn, N Girard… - Annals of …, 2022 - annalsofoncology.org
Incidence of malignant pleural mesothelioma (MPM) is generally higher in males than
females and is attributed to historical differences in exposures with world-standardised …

[HTML][HTML] Durvalumab with platinum-pemetrexed for unresectable pleural mesothelioma: survival, genomic and immunologic analyses from the phase 2 PrE0505 trial

PM Forde, V Anagnostou, Z Sun, SE Dahlberg… - Nature medicine, 2021 - nature.com
Mesothelioma is a rare and fatal cancer with limited therapeutic options until the recent
approval of combination immune checkpoint blockade. Here we report the results of the …

ERS/ESTS/EACTS/ESTRO guidelines for the management of malignant pleural mesothelioma

A Scherpereel, I Opitz, T Berghmans… - European respiratory …, 2020 - Eur Respiratory Soc
The European Respiratory Society (ERS)/European Society of Thoracic Surgeons
(ESTS)/European Association for Cardio-Thoracic Surgery (EACTS)/European Society for …

Durvalumab with first-line chemotherapy in previously untreated malignant pleural mesothelioma (DREAM): a multicentre, single-arm, phase 2 trial with a safety run-in

AK Nowak, WJ Lesterhuis, PS Kok, C Brown… - The Lancet …, 2020 - thelancet.com
Background There is a strong unmet need to improve systemic therapy in mesothelioma.
Chemotherapy with cisplatin and pemetrexed improves survival in malignant pleural …

Tumour Treating Fields in combination with pemetrexed and cisplatin or carboplatin as first-line treatment for unresectable malignant pleural mesothelioma (STELLAR …

GL Ceresoli, JG Aerts, R Dziadziuszko… - The Lancet …, 2019 - thelancet.com
Summary Background Tumour Treating Fields (TTFields) are a regional, antimitotic
treatment for solid tumours, which is based on the delivery of low-intensity alternating …

Gemcitabine with or without ramucirumab as second-line treatment for malignant pleural mesothelioma (RAMES): a randomised, double-blind, placebo-controlled …

C Pinto, PA Zucali, M Pagano, F Grosso… - The Lancet …, 2021 - thelancet.com
Background There is a preclinical rationale for inhibiting angiogenesis in mesothelioma. We
aimed to assess the efficacy and safety of the anti-VEGFR-2 antibody ramucirumab …

[HTML][HTML] EURACAN/IASLC proposals for updating the histologic classification of pleural mesothelioma: towards a more multidisciplinary approach

AG Nicholson, JL Sauter, AK Nowak, HL Kindler… - Journal of Thoracic …, 2020 - Elsevier
Introduction Molecular and immunologic breakthroughs are transforming the management of
thoracic cancer, although advances have not been as marked for malignant pleural …

New era for malignant pleural mesothelioma: updates on therapeutic options

AS Tsao, HI Pass, A Rimner… - Journal of Clinical …, 2022 - ascopubs.org
Malignant pleural mesothelioma (MPM) is a rare malignancy with few treatment options.
Recent advances have led to US Food and Drug Administration approvals and changes in …