The major concept of" oxidative stress" is an excess elevated level of reactive oxygen
species (ROS) which are generated from vigorous metabolism and consumption of oxygen …

Extensive research over the past half a century indicates that reactive oxygen species (ROS)
play an important role in cancer. Although low levels of ROS can be beneficial, excessive …

Mitochondria, the main provider of energy in eukaryotic cells, contains more than 1000
different proteins and is closely related to the development of cells. However, damaged …

Despite the evidences of elevated expression of Mer tyrosine kinase (MerTK) in multiple
human cancers, mechanisms underlying the oncogenic roles of MerTK in hepatocellular …

Lon protease is a nuclear-encoded, mitochondrial ATP-dependent protease highly
conserved throughout the evolution, crucial for the maintenance of mitochondrial …

Initially discovered as a protease responsible for degradation of misfolded or damaged
proteins, the mitochondrial Lon protease (Lonp1) turned out to be a multifaceted enzyme …

Colorectal cancer is one of the leading causes of cancer deaths worldwide. Currently,
chemotherapy is the primary way for colorectal cancer, but with severe side effects …

Lon protease is a nuclear DNA-encoded mitochondrial enzyme highly conserved throughout
evolution, involved in the degradation of damaged and oxidized proteins of the …

Mitochondrial transcription factor A (TFAM) is essential for the replication, transcription and
maintenance of mitochondrial DNA (mtDNA). The role of TFAM in non-small cell lung cancer …

Mitochondria are multifaceted metabolic organelles and adapt dynamically to various
developmental transitions and environmental challenges. The metabolic flexibility of …