Therapeutic targeting of α7 nicotinic acetylcholine receptors

RL Papke, NA Horenstein - Pharmacological Reviews, 2021 - ASPET
The α 7-type nicotinic acetylcholine receptor is one of the most unique and interesting of all
the members of the cys-loop superfamily of ligand-gated ion channels. Since it was first …

Nicotinic acetylcholine receptors: Conventional and unconventional ligands and signaling

RL Papke, JM Lindstrom - Neuropharmacology, 2020 - Elsevier
Postsynaptic nAChRs in the peripheral nervous system are critical for neuromuscular and
autonomic neurotransmission. Pre-and peri-synaptic nAChRs in the brain modulate …

α9: an acetylcholine receptor with novel pharmacological properties expressed in rat cochlear hair cells

AB Elgoyhen, DS Johnson, J Boulter, DE Vetter… - Cell, 1994 - cell.com
We report the isolation and functional characterization of a member of the nicotinic
acetylcholine receptor subunit gene family, cc9. Xenopus oocytes injected with a9 cRNA …

Distribution of alpha2, alpha3, alpha4, and beta2 neuronal nicotinic receptor subunit mRNAs in the central nervous system: a hybridization histochemical study in the …

E Wada, K Wada, JIM Boulter, E Deneris… - Journal of …, 1989 - Wiley Online Library
Previous studies have revealed the existence of a gene family that encodes a group of
neuronal nicotinic acetylcholine receptor (nAChR) subunits. Four members of this family …

Regulation of class I MHC gene expression in the developing and mature CNS by neural activity

RA Corriveau, GS Huh, CJ Shatz - Neuron, 1998 - cell.com
To elucidate molecular mechanisms underlying activity-dependent synaptic remodeling in
the developing mammalian visual system, we screened for genes whose expression in the …

A neuronal nicotinic acetylcholine receptor subunit (α7) is developmentally regulated and forms a homo-oligomeric channel blocked by α-BTX

S Couturier, D Bertrand, JM Matter, MC Hernandez… - Neuron, 1990 - cell.com
1211 Geneva 4 Switzerland* Department of Biochemistry and Genetics University of
Newcastle Newcastle upon Tyne England cDNA and genomic clones encoding a7, a novel …

[PDF][PDF] A subtype of nicotinic cholinergic receptor in rat brain is composed of alpha 4 and beta 2 subunits and is up-regulated by chronic nicotine treatment.

CM Flores, SW Rogers, LA Pabreza, BB Wolfe… - Molecular …, 1992 - Citeseer
The subunit composition and pharmacological regulation of rat neuronal nicotinic
cholinergic receptors were assessed. Specific immunoprecipitation was determined in …

The rat brain synucleins; family of proteins transiently associated with neuronal membrane

L Maroteaux, RH Scheller - Molecular brain research, 1991 - Elsevier
The synuclein cDNA was previously cloned from Torpedo califonica using an antiserum
against purified synaptic vesicles. Here we show that this gene hybridize to several clones in …

Nicotinic acetylcholine receptor an 9 Å resolution

N Unwin - Journal of molecular biology, 1993 - Elsevier
The nicotinic acetylcholine receptor is a cation-selective, ligand-gated ion channel, involved
in signal transmission at the chemical synapse. This paper reports the three-dimensional …

A New α-Conotoxin Which Targets α3β2 Nicotinic Acetylcholine Receptors (∗)

GE Cartier, D Yoshikami, WR Gray, S Luo… - Journal of Biological …, 1996 - ASBMB
We have isolated a 16-amino acid peptide from the venom of the marine snail Conus magus
which potently blocks nicotinic acetylcholine receptors (nAChRs) composed of α3β2 …