Curcumin: an inflammasome silencer
Curcumin is the major bioactive polyphenolic ingredient of turmeric. Increasing evidence
indicates that the health benefits of curcumin are mediated through its anti-inflammatory and …
indicates that the health benefits of curcumin are mediated through its anti-inflammatory and …
[HTML][HTML] Turmeric-derived nanovesicles as novel nanobiologics for targeted therapy of ulcerative colitis
C Gao, Y Zhou, Z Chen, H Li, Y Xiao, W Hao, Y Zhu… - Theranostics, 2022 - ncbi.nlm.nih.gov
Abstract Rationale: Ulcerative colitis (UC), a typical kind of inflammatory bowel disease
(IBD), is an idiopathic chronic intestinal inflammation. Conventional therapeutic strategies …
(IBD), is an idiopathic chronic intestinal inflammation. Conventional therapeutic strategies …
Involvement of inflammasomes in tumor microenvironment and tumor therapies
Z Zhang, X Li, Y Wang, Y Wei, X Wei - Journal of Hematology & Oncology, 2023 - Springer
Inflammasomes are macromolecular platforms formed in response to damage-associated
molecular patterns (DAMPs) and pathogen-associated molecular patterns, whose formation …
molecular patterns (DAMPs) and pathogen-associated molecular patterns, whose formation …
Anti-inflammatory effects of curcumin in the inflammatory diseases: Status, limitations and countermeasures
Y Peng, M Ao, B Dong, Y Jiang, L Yu… - Drug design …, 2021 - Taylor & Francis
Curcumin is a natural compound with great potential for disease treatment. A large number
of studies have proved that curcumin has a variety of biological activities, among which anti …
of studies have proved that curcumin has a variety of biological activities, among which anti …
NLRP3 inflammasome mediates M1 macrophage polarization and IL‐1β production in inflammatory root resorption
J Zhang, X Liu, C Wan, Y Liu, Y Wang… - Journal of Clinical …, 2020 - Wiley Online Library
Aims To explore the involvement of NOD‐like receptor protein 3 (NLRP3) inflammasome
and M1 macrophage in root resorption (RR). Methods A rat RR model was established by …
and M1 macrophage in root resorption (RR). Methods A rat RR model was established by …
Roles of PRR-mediated signaling pathways in the regulation of oxidative stress and inflammatory diseases
P Li, M Chang - International journal of molecular sciences, 2021 - mdpi.com
Oxidative stress is a major contributor to the pathogenesis of various inflammatory diseases.
Accumulating evidence has shown that oxidative stress is characterized by the …
Accumulating evidence has shown that oxidative stress is characterized by the …
[HTML][HTML] Curcumin attenuates potassium oxonate-induced hyperuricemia and kidney inflammation in mice
Y Chen, C Li, S Duan, X Yuan, J Liang… - Biomedicine & …, 2019 - Elsevier
Current evidences suggest that hyperuricemia is closely related to the overproduction or
underexcretion of uric acid (UA). Curcumin (CUR), a natural polyphenol component …
underexcretion of uric acid (UA). Curcumin (CUR), a natural polyphenol component …
WTAP-mediated N6-methyladenosine modification of NLRP3 mRNA in kidney injury of diabetic nephropathy
J Lan, B Xu, X Shi, Q Pan, Q Tao - Cellular & Molecular Biology Letters, 2022 - Springer
Background Diabetic nephropathy (DN) is prevalent in patients with diabetes. N 6-
methyladenosine (m6A) methylation has been found to cause modification of nucleotide …
methyladenosine (m6A) methylation has been found to cause modification of nucleotide …
Curcumin attenuates MSU crystal-induced inflammation by inhibiting the degradation of IκBα and blocking mitochondrial damage
B Chen, H Li, G Ou, L Ren, X Yang, M Zeng - Arthritis research & therapy, 2019 - Springer
Background Gouty arthritis is characterized by the deposition of monosodium urate (MSU)
within synovial joints and tissues due to increased urate concentrations. In this study, we …
within synovial joints and tissues due to increased urate concentrations. In this study, we …