[HTML][HTML] Therapeutic implications of inflammasome in inflammatory bowel disease

V Khatri, R Kalyanasundaram - FASEB journal: official publication …, 2021 - ncbi.nlm.nih.gov
Inflammatory bowel disease (IBD) remains a persistent health problem with a global burden
surging over 6.8 million cases currently. Clinical pathology of IBD is complicated; however …

[HTML][HTML] NLRP3 inflammasome in digestive diseases: from mechanism to therapy

R Qiang, Y Li, X Dai, W Lv - Frontiers in Immunology, 2022 - frontiersin.org
Digestive system diseases remain a formidable challenge to human health. NOD-like
receptor family pyrin domain containing 3 (NLRP3) inflammasome is the most characteristic …

[HTML][HTML] NLRP3-mediated inflammation in atherosclerosis and associated therapeutics

N Lu, W Cheng, D Liu, G Liu, C Cui, C Feng… - Frontiers in Cell and …, 2022 - frontiersin.org
The NLRP3 inflammasome is an important part of the body's innate immune system, and a
multiprotein platform which is activated by recognizing pathogen-associated molecular …

[HTML][HTML] Medicinal plants, phytochemicals and regulation of the NLRP3 inflammasome in inflammatory bowel diseases: A comprehensive review

R Direito, SM Barbalho, ME Figueira, G Minniti… - Metabolites, 2023 - mdpi.com
Ongoing research explores the underlying causes of ulcerative colitis and Crohn's disease.
Many experts suggest that dysbiosis in the gut microbiota and genetic, immunological, and …

Polyphenols and inflammatory bowel disease: Natural products with therapeutic effects?

M Vaghari-Tabari, F Alemi, M Zokaei… - Critical Reviews in …, 2024 - Taylor & Francis
Inflammatory bowel disease (IBD) is a long-life disease with periods of recurrence and relief.
Oxidative stress plays an important role in the pathogenesis of this disease. Recent years' …

Lactobacillus casei ATCC 393 and it's metabolites alleviate dextran sulphate sodium-induced ulcerative colitis in mice through the NLRP3-(Caspase-1)/IL-1β pathway

X Dou, L Qiao, J Chang, S Yan, X Song, Y Chen… - Food & Function, 2021 - pubs.rsc.org
Inflammatory bowel disease (IBD) represents a broad group of intestinal disorders, including
ulcerative colitis (UC) and Crohn's disease (CD). Probiotics are increasingly being …

Curcumin improves epithelial barrier integrity of Caco‐2 monolayers by inhibiting endoplasmic reticulum stress and subsequent apoptosis

X Zhou, M Ren, J Yang, H Pan… - … Research and Practice, 2021 - Wiley Online Library
Curcumin is a natural polyphenol and is supposed to possess antioxidant, anti‐
inflammatory, anticancer, and antiapoptotic properties. Although some studies have reported …

Curcumin attenuates murine lupus via inhibiting NLRP3 inflammasome

J Zhao, J Wang, M Zhou, M Li, M Li, H Tan - International …, 2019 - Elsevier
Despite rapid progress in the understanding of systemic lupus erythematosus (SLE), there is
still an urgent need for novel and more effective interventions. Curcumin, a natural …

[HTML][HTML] The role of cholesterol and mitochondrial bioenergetics in activation of the inflammasome in IBD

J Astorga, N Gasaly, K Dubois-Camacho… - Frontiers in …, 2022 - frontiersin.org
Inflammatory Bowel Disease (IBD) is characterized by a loss of intestinal barrier function
caused by an aberrant interaction between the immune response and the gut microbiota. In …

Jatrorrhizine Alleviates DSS‐Induced Ulcerative Colitis by Regulating the Intestinal Barrier Function and Inhibiting TLR4/MyD88/NF‐κB Signaling Pathway

S Niu, M Jing, J Wen, S Wei, H Li, X Li… - Evidence‐Based …, 2022 - Wiley Online Library
Background. Ulcerative colitis (UC), a kind of autoimmune disease with unknown etiology,
has been troubling human physical and mental health. Jatrorrhizine (Jat) is a natural …