Nanoparticles in drug delivery: From history to therapeutic applications
Current research into the role of engineered nanoparticles in drug delivery systems (DDSs)
for medical purposes has developed numerous fascinating nanocarriers. This paper reviews …
for medical purposes has developed numerous fascinating nanocarriers. This paper reviews …
Delivery of oligonucleotide‐based therapeutics: challenges and opportunities
SM Hammond, A Aartsma‐Rus, S Alves… - EMBO molecular …, 2021 - embopress.org
Nucleic acid‐based therapeutics that regulate gene expression have been developed
towards clinical use at a steady pace for several decades, but in recent years the field has …
towards clinical use at a steady pace for several decades, but in recent years the field has …
The current state of peptide drug discovery: back to the future?
A Henninot, JC Collins, JM Nuss - Journal of medicinal chemistry, 2018 - ACS Publications
Over the past decade, peptide drug discovery has experienced a revival of interest and
scientific momentum, as the pharmaceutical industry has come to appreciate the role that …
scientific momentum, as the pharmaceutical industry has come to appreciate the role that …
Tricyclic cell-penetrating peptides for efficient delivery of functional antibodies into cancer cells
The intracellular environment hosts a large number of cancer-and other disease-relevant
human proteins. Targeting these with internalized antibodies would allow therapeutic …
human proteins. Targeting these with internalized antibodies would allow therapeutic …
Bone-targeted nanoplatform combining zoledronate and photothermal therapy to treat breast cancer bone metastasis
W Sun, K Ge, Y Jin, Y Han, H Zhang, G Zhou, X Yang… - ACS …, 2019 - ACS Publications
Bone metastasis, a clinical complication of patients with advanced breast cancer, seriously
reduces the quality of life. To avoid destruction of the bone matrix, current treatments focus …
reduces the quality of life. To avoid destruction of the bone matrix, current treatments focus …
Intracellular Mechanistic Understanding of 2D MoS2 Nanosheets for Anti-Exocytosis-Enhanced Synergistic Cancer Therapy
Emerging two-dimensional (2D) nanomaterials, such as transition-metal dichalcogenide
(TMD) nanosheets (NSs), have shown tremendous potential for use in a wide variety of …
(TMD) nanosheets (NSs), have shown tremendous potential for use in a wide variety of …
[HTML][HTML] Peptides for nucleic acid delivery
Nucleic acids and their synthetic oligonucleotide (ON) analogs are a group of gene
therapeutic compounds which hold enormous clinical potential. Despite their undoubted …
therapeutic compounds which hold enormous clinical potential. Despite their undoubted …
Delivery of therapeutic oligonucleotides with cell penetrating peptides
P Boisguérin, S Deshayes, MJ Gait… - Advanced drug delivery …, 2015 - Elsevier
Oligonucleotide-based drugs have received considerable attention for their capacity to
modulate gene expression very specifically and as a consequence they have found …
modulate gene expression very specifically and as a consequence they have found …
Predicting cell-penetrating peptides using machine learning algorithms and navigating in their chemical space
ECL de Oliveira, K Santana, L Josino… - Scientific reports, 2021 - nature.com
Cell-penetrating peptides (CPPs) are naturally able to cross the lipid bilayer membrane that
protects cells. These peptides share common structural and physicochemical properties and …
protects cells. These peptides share common structural and physicochemical properties and …
Redesigning of cell-penetrating peptides to improve their efficacy as a drug delivery system
Cell-penetrating peptides (CPP) are promising tools for the transport of a broad range of
compounds into cells. Since the discovery of the first members of this peptide family, many …
compounds into cells. Since the discovery of the first members of this peptide family, many …