Evasion of immune system is a hallmark of cancer, which enables cancer cells to escape the
attack from immune cells. Cancer cells can express many immune inhibitory signalling …

Eph receptors and the corresponding Eph receptor-interacting (ephrin) ligands jointly
constitute a critical cell signaling network that has multiple functions. The tyrosine kinase …

The genetic modification and characterization of T-cells with chimeric antigen receptors
(CARs) allow functionally distinct T-cell subsets to recognize specific tumor cells. The …

Traditional cancer treatments use nonspecific drugs and monoclonal antibodies to target
tumor cells. Chimeric antigen receptor (CAR)-T cell therapy, however, leverages the immune …

Building upon the resounding therapeutic success of monoclonal antibodies, and supported
by accelerating progress in engineering methods, the field of multispecific therapeutic …

Engagement of the T cell receptor complex reprograms T cells for proliferation, cytokine
production and differentiation towards effector cells. This process depends on activating …

Chimeric antigen receptor (CAR) development is biased toward selecting constructs that
elicit the highest magnitude of T-cell functional outputs. Here, we show that components of …

Background Acute myeloid leukemia (AML) is one of the most common types of adult acute
leukemia. Standard chemotherapies can induce complete remission in selected patients; …

Simple Summary Chimeric antigen receptors (CARs) targeting CD19 have emerged as a
new treatment for hematological malignancies. As a “living therapy”, CARs can precisely …

Cancer is a leading cause of death worldwide; due to the lack of ideal cancer biomarkers for
early detection or diagnosis, most patients present with late-stage disease at the time of …