Connecting copper and cancer: from transition metal signalling to metalloplasia

EJ Ge, AI Bush, A Casini, PA Cobine, JR Cross… - Nature Reviews …, 2022 - nature.com
Copper is an essential nutrient whose redox properties make it both beneficial and toxic to
the cell. Recent progress in studying transition metal signalling has forged new links …

Copper-induced tumor cell death mechanisms and antitumor theragnostic applications of copper complexes

Y Jiang, Z Huo, X Qi, T Zuo, Z Wu - Nanomedicine, 2022 - Future Medicine
Recent studies found that unbalanced copper homeostasis affect tumor growth, causing
irreversible damage. Copper can induce multiple forms of cell death, including apoptosis …

Advanced liposome and polymersome-based drug delivery systems: Considerations for physicochemical properties, targeting strategies and stimuli-sensitive …

S Kansız, YM Elçin - Advances in Colloid and Interface Science, 2023 - Elsevier
Liposomes and polymersomes are colloidal vesicles that are self-assembled from lipids and
amphiphilic polymers, respectively. Because of their ability to encapsulate both hydrophilic …

Copper: an intracellular achilles' heel allowing the targeting of epigenetics, kinase pathways, and cell metabolism in cancer therapeutics

F Michniewicz, F Saletta, JRC Rouaen… - …, 2021 - Wiley Online Library
Copper is an essential transition metal frequently increased in cancer known to strongly
influence essential cellular processes. Targeted therapy protocols utilizing both novel and …

[HTML][HTML] Red blood cell extracellular vesicle-based drug delivery: challenges and opportunities

W Chiangjong, P Netsirisawan, S Hongeng… - Frontiers in …, 2021 - frontiersin.org
Recently, red blood cell-derived extracellular vesicles (RBCEVs) have attracted attention for
clinical applications because of their safety and biocompatibility. RBCEVs can escape …

Safety of gold nanoparticles: from in vitro to in vivo testing array checklist

J Lopes, T Ferreira-Gonçalves, L Ascensão, AS Viana… - Pharmaceutics, 2023 - mdpi.com
In recent years, gold nanoparticles (AuNPs) have aroused the interest of many researchers
due to their unique physicochemical and optical properties. AuNPs are being explored in a …

[HTML][HTML] Cuproptosis: A novel therapeutic target for overcoming cancer drug resistance

Y Wang, Y Chen, J Zhang, Y Yang, JS Fleishman… - Drug Resistance …, 2023 - Elsevier
Cuproptosis is a newly identified form of cell death driven by copper. Recently, the role of
copper and copper triggered cell death in the pathogenesis of cancers have attracted …

Advancing Medicine with Lipid-Based Nanosystems—The Successful Case of Liposomes

H Luiz, J Oliveira Pinho, MM Gaspar - Biomedicines, 2023 - mdpi.com
Nanomedicine, a promising area of medicine, employs nanosized tools for the diagnosis,
prevention, and treatment of disease. Particularly, liposomes, lipid-based nanovesicles, are …

Liposomal formulations of a new zinc (II) complex exhibiting high therapeutic potential in a murine colon cancer model

N Ribeiro, M Albino, A Ferreira, C Escrevente… - International Journal of …, 2022 - mdpi.com
Colorectal cancer is the second leading cause of cancer-related mortality. Many current
therapies rely on chemotherapeutic agents with poor specificity for tumor cells. The clinical …

[HTML][HTML] Aquaglyceroporin modulators as emergent pharmacological molecules for human diseases

C Pimpão, D Wragg, IV da Silva, A Casini… - Frontiers in Molecular …, 2022 - frontiersin.org
Aquaglyceroporins, a sub-class of aquaporins that facilitate the diffusion of water, glycerol
and other small uncharged solutes across cell membranes, have been recognized for their …