Current trends in the development of liposomes for chemotherapeutic drug delivery

S Kumbham, S Ajjarapu, B Ghosh, S Biswas - Journal of Drug Delivery …, 2023 - Elsevier
Published literature on cancer by health agencies and health organizations reveals
increased cancer incidence year by year. The first line of cancer treatment involves one or …

Liposomal formulations of a new zinc (II) complex exhibiting high therapeutic potential in a murine colon cancer model

N Ribeiro, M Albino, A Ferreira, C Escrevente… - International Journal of …, 2022 - mdpi.com
Colorectal cancer is the second leading cause of cancer-related mortality. Many current
therapies rely on chemotherapeutic agents with poor specificity for tumor cells. The clinical …

Metal coordination and biological screening of a Schiff Base derived from 8-hydroxyquinoline and benzothiazole

N Ribeiro, PF Farinha, JO Pinho, H Luiz, JP Mészáros… - Pharmaceutics, 2022 - mdpi.com
Designing new metallodrugs for anticancer therapy is a driving force in the scientific
community. Aiming to contribute to this field, we hereby report the development of a Schiff …

Copper and Copper Complexes in Tumor Therapy

Y Wang, T Tang, Y Yuan, N Li, X Wang… - ChemMedChem, 2024 - Wiley Online Library
Copper (Cu), a crucial trace element in physiological processes, has garnered significant
interest for its involvement in cancer progression and potential therapeutic applications. The …

Aquaglyceroporin modulators as emergent pharmacological molecules for human diseases

C Pimpão, D Wragg, IV da Silva, A Casini… - Frontiers in Molecular …, 2022 - frontiersin.org
Aquaglyceroporins, a sub-class of aquaporins that facilitate the diffusion of water, glycerol
and other small uncharged solutes across cell membranes, have been recognized for their …

[HTML][HTML] A step forward on the in vitro and in vivo assessment of a novel nanomedicine against melanoma

JO Pinho, M Matias, A Godinho-Santos… - International Journal of …, 2023 - Elsevier
Melanoma is the most aggressive form of skin cancer, with increasing incidence and
mortality rates. To overcome current treatment limitations, a hybrid molecule (HM) combining …

Blockage of aquaporin‐3 peroxiporin activity by organogold compounds affects melanoma cell adhesion, proliferation and migration

IV da Silva, C Pimpão, I Paccetti‐Alves… - The Journal of …, 2024 - Wiley Online Library
Abstract Aquaporin‐3 (AQP3) is a membrane channel with dual aquaglyceroporin/
peroxiporin activity, facilitating the diffusion of water, glycerol and H2O2 across cell …

Copper Coordination‐Based Nanomedicine for Tumor Theranostics

Y Han, N Xie, W Zhou - Advanced Therapeutics, 2024 - Wiley Online Library
Copper (Cu) is an essential micronutrient for a variety of basic biological processes,
including cell metabolism, proliferation, and angiogenesis. Recently, the concept of …

Peroxiporins are induced upon oxidative stress insult and are associated with oxidative stress resistance in colon cancer cell lines

A Čipak Gašparović, L Milković, C Rodrigues… - Antioxidants, 2021 - mdpi.com
Oxidative stress can induce genetic instability and change cellular processes, resulting in
colorectal cancer. Additionally, adaptation of oxidative defense causes therapy resistance, a …

Aquaporin-3 and aquaporin-5 facilitate migration and cell–cell adhesion in pancreatic cancer by modulating cell biomechanical properties

PM Silva, IV da Silva, MJ Sarmento, ÍC Silva… - Cells, 2022 - mdpi.com
Background: Aquaporins are membrane channels responsible for the bidirectional transfer
of water and small non-charged solutes across cell membranes. AQP3 and AQP5 are …