Immunomodulatory properties of human breast milk: microRNA contents and potential epigenetic effects

MMM Hatmal, MAI Al-Hatamleh, AN Olaimat, W Alshaer… - Biomedicines, 2022 - mdpi.com
Infants who are exclusively breastfed in the first six months of age receive adequate
nutrients, achieving optimal immune protection and growth. In addition to the known …

The sexual dimorphism of human adipose depots

N Boulet, A Briot, J Galitzky, A Bouloumié - Biomedicines, 2022 - mdpi.com
The amount and the distribution of body fat exhibit trajectories that are sex-and human
species-specific and both are determinants for health. The enhanced accumulation of fat in …

A spatially resolved single-cell genomic atlas of the adult human breast

T Kumar, K Nee, R Wei, S He, QH Nguyen, S Bai… - Nature, 2023 - nature.com
The adult human breast is comprised of an intricate network of epithelial ducts and lobules
that are embedded in connective and adipose tissue,–. Although most previous studies have …

The adipose organ is a unitary structure in mice and humans

A Giordano, F Cinti, R Canese, G Carpinelli… - Biomedicines, 2022 - mdpi.com
Obesity is the fifth leading cause of death worldwide. In mice and humans with obesity, the
adipose organ undergoes remarkable morpho-functional alterations. The comprehension of …

A role for adipocytes and adipose stem cells in the breast tumor microenvironment and regenerative medicine

CK Brock, KL Hebert, M Artiles, MK Wright… - Frontiers in …, 2021 - frontiersin.org
Obesity rates are climbing, representing a confounding and contributing factor to many
disease states, including cancer. With respect to breast cancer, obesity plays a prominent …

A cell transcriptomic profile provides insights into adipocytes of porcine mammary gland across development

Y Fan, L Jin, Z He, T Wei, T Luo, J Zhang, C Liu… - Journal of Animal …, 2023 - Springer
Background Studying the composition and developmental mechanisms in mammary gland
is crucial for healthy growth of newborns. The mammary gland is inherently heterogeneous …

Tissue-specific Warburg effect in breast cancer and cancer-associated adipose tissue—relationship between AMPK and glycolysis

A Kalezic, M Udicki, B Srdic Galic, M Aleksic, A Korac… - Cancers, 2021 - mdpi.com
Simple Summary Specific metabolic phenotypes of breast cancer result from local
interactions such as cancer-adipocyte cross-talk and systemic metabolic influences such as …

Obese adipocytes have altered redox homeostasis with metabolic consequences

S Cinti - Antioxidants, 2023 - mdpi.com
White and brown adipose tissues are organized to form a real organ, the adipose organ, in
mice and humans. White adipocytes of obese animals and humans are hypertrophic. This …

Management of obesity across women's life course: FIGO Best Practice Advice

CV Maxwell, R Shirley, AC O'Higgins… - … of Gynecology & …, 2023 - Wiley Online Library
Obesity is a chronic, progressive, relapsing, and treatable multifactorial, neurobehavioral
disease. According to the World Health Organization, obesity affects 15% of women and has …

From obesity to diabetes: the role of the adipose organ

G Colleluori, J Perugini, A Giordano, S Cinti - From Obesity to Diabetes, 2022 - Springer
Obesity is a complex, multifactorial, and relapsing disease whose prevalence has tripled
during the last decades and whose incidence is expected to further increase. For these …