HIV virus particles interact with several receptors on cell surfaces. Two receptors, CD4 and a
co-receptor act sequentially to trigger fusion of viral and cellular membranes and confer …

Although the CD4 molecule is the principal cellular receptor for the human
immunodeficiency virus (HIV), several CD4-negative cell lines are susceptible to infection …

Human immunodeficiency virus (HIV) exploits cell surface receptors to attach to and gain
entry into cells. The HIV envelope spike glycoprotein on the surface of virus particles binds …

The role of cell-surface proteoglycans in human immunodeficiency virus (HIV) infection of T-
cell lines was investigated. HIV-1-susceptible lymphoblastic T-cell lines, MT-4 and H9, were …

We have investigated the molecular basis of biological differences observed among cell line-
adapted isolates of the human immunodeficiency virus types 1 and 2 (HIV-1 and HIV-2) and …

The intracellular processing of the gp160 HIV-1 envelope precursor was characterized in
acutely infected CD4+ T cells. Our data show that gp160 undergoes endoproteolytic …

To evaluate the presence and distribution of central nervous system infection by human
immunodeficiency virus type 1 (HIV‐1), we used immunohistochemical methods to map the …

The initial steps in virus infection involve the binding of virions to specific cell surface
receptors. Following the attachment of enveloped viruses, further events lead to membrane …

Entry of human immunodeficiency virus type 1 (HIV-1) requires CD4 and one of a family of
related seven-transmembrane-domain coreceptors. Macrophage-tropic HIV-1 isolates are …

We have presented evidence in this review for the following:(a) Macrophages are likely the
first cell infected by HIV. Recovery of HIV from macrophages has been documented in the …