Investigations into the mechanism by which sulfated polysaccharides inhibit HIV infection in vitro

MO McCLURE, JP MOORE, DF BLANC… - AIDS Research and …, 1992 - liebertpub.com
Sulfated polysaccharides have been shown to inhibit human immunodeficiency virus (HIV)
infection in vitro. Dextrin sulfate, fucoidan, and dextran sulfate fail to neutralize virions …

Persistent human immunodeficiency virus type 1 infection in human fetal glial cells reactivated by T-cell factor (s) or by the cytokines tumor necrosis factor alpha and …

C Tornatore, A Nath, K Amemiya, EO Major - Journal of virology, 1991 - Am Soc Microbiol
Human immunodeficiency virus type 1 (HIV-1) infection of the brain has been associated
with a severe dementing illness in children and adults. However, HIV-1 antigens are most …

Molecular biology of the human immunodeficiency virus type 1

WA Haseltine - The FASEB journal, 1991 - Wiley Online Library
The immunodeficiency virus type 1 is a complex retrovirus. In addition to genes that specify
the proteins of the virus particle and the replicative enzymes common to all retroviruses, HIV …

Antiretroviral therapy and drug resistance in human immunodeficiency virus type 2 infection

L Menéndez-Arias, M Álvarez - Antiviral research, 2014 - Elsevier
One to two million people worldwide are infected with the human immunodeficiency virus
type 2 (HIV-2), with highest prevalences in West African countries, but also present in …

The CD4-gp120 interaction and AIDS pathogenesis.

DJ Capon, RH Ward - Annual review of immunology, 1991 - europepmc.org
Infection by the human immunodeficiency virus (HIV) leads to progressive destruction of the
CD4+ subset of T lymphocytes, resulting in immunodeficiency and AIDS. The selectivity of …

Virions of primary human immunodeficiency virus type 1 isolates resistant to soluble CD4 (sCD4) neutralization differ in sCD4 binding and glycoprotein gp120 …

JP Moore, JA McKeating, YX Huang… - Journal of …, 1992 - Am Soc Microbiol
Primary isolates of human immunodeficiency virus type 1 (HIV-1) are much less sensitive to
neutralization by soluble CD4 (sCD4) and sCD4-immunoglobulin (Ig) chimeras (CD4-IgG) …

Galactosyl ceramide or a derivative is an essential component of the neural receptor for human immunodeficiency virus type 1 envelope glycoprotein gp120.

S Bhat, SL Spitalnik… - Proceedings of the …, 1991 - National Acad Sciences
This report demonstrates that galactosyl ceramide (GalCer) or a molecule derived from it
may serve as an alternative receptor for human immunodeficiency virus in the nervous …

Infection of brain microglial cells by human immunodeficiency virus type 1 is CD4 dependent

CA Jordan, BA Watkins, C Kufta… - Journal of …, 1991 - Am Soc Microbiol
In the central nervous system of AIDS patients, human immunodeficiency virus (HIV) infects
primarily microglia, a cell type of bone marrow origin. Moreover, microglial cells isolated …

Glucosylceramide and galactosylceramide, small glycosphingolipids with significant impact on health and disease

S Reza, M Ugorski, J Suchański - Glycobiology, 2021 - academic.oup.com
Numerous clinical observations and exploitation of cellular and animal models indicate that
glucosylceramide (GlcCer) and galactosylceramide (GalCer) are involved in many …

Specific cell surface requirements for the infection of CD4-positive cells by human immunodeficiency virus types 1 and 2 and by simian immunodeficiency virus

PR Clapham, D Blanc, RA Weiss - Virology, 1991 - Elsevier
Human CD4 was expressed on a range of mammalian cell lines. CD4+ non-primate cells,
derived from rat, hamster, mink, cat, and rabbit, bind recombinant gp120 of human …