First Organoid Intelligence (OI) workshop to form an OI community

IE Morales Pantoja, L Smirnova, AR Muotri… - Frontiers in Artificial …, 2023 - frontiersin.org
The brain is arguably the most powerful computation system known. It is extremely efficient
in processing large amounts of information and can discern signals from noise, adapt, and …

[HTML][HTML] Gut-on-a-chip models for dissecting the gut microbiology and physiology

A Valiei, J Aminian-Dehkordi, MRK Mofrad - APL bioengineering, 2023 - pubs.aip.org
Microfluidic technologies have been extensively investigated in recent years for developing
organ-on-a-chip-devices as robust in vitro models aiming to recapitulate organ 3D …

Spontaneous preterm birth: Involvement of multiple feto-maternal tissues and organ systems, differing mechanisms, and pathways

MS Vidal Jr, RCV Lintao, MEL Severino… - Frontiers in …, 2022 - frontiersin.org
Survivors of preterm birth struggle with multitudes of disabilities due to improper in utero
programming of various tissues and organ systems contributing to adult-onset diseases at a …

Chitosan and pectin hydrogels for tissue engineering and in vitro modeling

G Morello, G De Iaco, G Gigli, A Polini, F Gervaso - Gels, 2023 - mdpi.com
Hydrogels are fascinating biomaterials that can act as a support for cells, ie, a scaffold, in
which they can organize themselves spatially in a similar way to what occurs in vivo …

Integration of extracellular matrices into organ‐on‐chip systems

H Kutluk, EE Bastounis… - Advanced Healthcare …, 2023 - Wiley Online Library
The extracellular matrix (ECM) is a complex, dynamic network present within all tissues and
organs that not only acts as a mechanical support and anchorage point but can also direct …

Engineering organ-on-a-chip to accelerate translational research

J Ko, D Park, S Lee, B Gumuscu, NL Jeon - Micromachines, 2022 - mdpi.com
We guide the use of organ-on-chip technology in tissue engineering applications. Organ-on-
chip technology is a form of microengineered cell culture platform that elaborates the in-vivo …

The FDA modernisation act 2.0: bringing non-animal technologies to the regulatory table

A Stewart, D Denoyer, X Gao, YC Toh - Drug discovery today, 2023 - Elsevier
The FDA modernisation Act 2.0 marks a game-changing legislation enabling drug
registration without the absolute requirement for the use of animals in safety toxicology …

Engineering Mesoscopic 3D Tumor Models with a Self‐Organizing Vascularized Matrix

F De Lorenzi, N Hansen, B Theek, R Daware… - Advanced …, 2024 - Wiley Online Library
Advanced in vitro systems such as multicellular spheroids and lab‐on‐a‐chip devices have
been developed, but often fall short in reproducing the tissue scale and self‐organization of …

Bioprinting 3D muscle tissue supplemented with endothelial-spheroids for neuromuscular junction model

WJ Kim, GH Kim - Applied Physics Reviews, 2023 - pubs.aip.org
The neuromuscular junction (NMJ) plays a critical role in muscle contraction, and its
dysfunction can result in various neuromuscular disorders. In vitro models for studying NMJ …

Magnetic‐Based Strategies for Regenerative Medicine and Tissue Engineering

LF Santos, AS Silva, JF Mano - Advanced Healthcare Materials, 2023 - Wiley Online Library
The fabrication of biological substitutes to repair, replace, or enhance tissue‐and organ‐
level functions is a long‐sought goal of tissue engineering (TE). However, the clinical …