[HTML][HTML] Nutrient synergy: Definition, evidence, and future directions

JR Townsend, TO Kirby, PA Sapp, AM Gonzalez… - Frontiers in …, 2023 - frontiersin.org
Nutrient synergy refers to the concept that the combined effects of two or more nutrients
working together have a greater physiological impact on the body than when each nutrient is …

[HTML][HTML] Insights into microfabrication and implementation of microfluidics in pharmaceutical drug delivery and analysis

OA Al-wdan, OA Sharallah, NA Abdelwahab… - OpenNano, 2023 - Elsevier
Microfluidics are systems that set forth valuable means to efficiently control fluid movement
and dynamics in specially fabricated micro-channel systems. The advancement of the …

AI-Powered Microfluidics: Shaping the Future of Phenotypic Drug Discovery

J Liu, H Du, L Huang, W Xie, K Liu… - … Applied Materials & …, 2024 - ACS Publications
Phenotypic drug discovery (PDD), which involves harnessing biological systems directly to
uncover effective drugs, has undergone a resurgence in recent years. The rapid …

From animal testing to in vitro systems: advancing standardization in microphysiological systems

DR Reyes, MB Esch, L Ewart, R Nasiri, A Herland… - Lab on a Chip, 2024 - pubs.rsc.org
Limitations with cell cultures and experimental animal-based studies have had the scientific
and industrial communities searching for new approaches that can provide reliable human …

Pump‐less platform enables long‐term recirculating perfusion of 3D printed tubular tissues

F Zhang, DSY Lin, S Rajasekar… - Advanced Healthcare …, 2023 - Wiley Online Library
The direction and pattern of fluid flow affect vascular structure and function, in which vessel‐
lining endothelial cells exhibit variable cellular morphologies and vessel remodeling by …

Opportunities for Microphysiological Systems in Toxicity Testing of New Drug Modalities

TI Maulana, NR Wevers, T Kristoforus… - Annual Review of …, 2025 - annualreviews.org
New drug modalities offer life-saving benefits for patients through access to previously
undruggable targets. Yet these modalities pose a challenge for the pharmaceutical industry …

Polymer-based drug delivery systems under investigation for enzyme replacement and other therapies of lysosomal storage disorders

M Placci, MI Giannotti, S Muro - Advanced drug delivery reviews, 2023 - Elsevier
Lysosomes play a central role in cellular homeostasis and alterations in this compartment
associate with many diseases. The most studied example is that of lysosomal storage …

[HTML][HTML] Organ-on-a-chip microengineering for bio-mimicking disease models and revolutionizing drug discovery

T Ahmed - Biosensors and Bioelectronics: X, 2022 - Elsevier
The core of the drug research and screening processes is predicting the effect of drugs prior
to human clinical trials. Due to the 2D cell culture and animal models' poor predictability, the …

[HTML][HTML] Breaking the clean room barrier: exploring low-cost alternatives for microfluidic devices

CF Rodríguez, V Andrade-Pérez, MC Vargas… - … in Bioengineering and …, 2023 - frontiersin.org
Microfluidics is an interdisciplinary field that encompasses both science and engineering,
which aims to design and fabricate devices capable of manipulating extremely low volumes …

[HTML][HTML] Cancer-on-chip: a 3D model for the study of the tumor microenvironment

E Cauli, MA Polidoro, S Marzorati, C Bernardi… - Journal of Biological …, 2023 - Springer
The approval of anticancer therapeutic strategies is still slowed down by the lack of models
able to faithfully reproduce in vivo cancer physiology. On one hand, the conventional in vitro …