ABSTRACT A vast array of successive epigenetic modifications ensures the creation of a
healthy individual. Crucial epigenetic reprogramming events occur during germ cell …

The ten–eleven translocation (TET) family of dioxygenases consists of three members,
TET1, TET2, and TET3. All three TET enzymes have Fe+ 2 and α-ketoglutarate (α-KG) …

Geneticists study the gene; however, for epigeneticists, there is no obvious' epigene'.
Nevertheless, during the past year, more than 2,500 articles, numerous scientific meetings …

We report the application of single-molecule-based sequencing technology for high-
throughput profiling of histone modifications in mammalian cells. By obtaining over four …

Tissue specific patterns of methylated cytosine residues vary with age, can be altered by
environmental factors, and are often abnormal in human disease yet the cellular …

Cancer is a complex disease resulting from the genetic and epigenetic disruption of normal
cells. The mechanistic understanding of the pathways involved in tumor transformation has …

TET family enzymes convert 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC) in
DNA. Here, we show that Tet1 and Tet2 are Oct4-regulated enzymes that together sustain …

Alzheimer's disease (AD) is a neurodegenerative disease with unknown pathogenesis and
complex pathological manifestations. At present, a large number of studies on targeted …

Dnmt2 proteins are the most conserved members of the DNA methyltransferase enzyme
family, but their substrate specificity and biological functions have been a subject of …

Epidemiological evidence increasingly suggests that environmental exposures early in
development have a role in susceptibility to disease in later life. In addition, some of these …