Context Our genome adapts to environmental influences, in part through epigenetic
mechanisms, including DNA methylation. Variations in the quality of the early environment …

To gain insight into the function of DNA methylation at cis-regulatory regions and its impact
on gene expression, we measured methylation, RNA polymerase occupancy and histone …

Mononuclear phagocytes are an important component of an innate immune system
perceived as a system ready to react upon encounter of pathogens. Here, we show that in …

Arsenic is a metalloid, that is, considered to be a human carcinogen. Millions of individuals
worldwide are chronically exposed through drinking water, with consequences ranging from …

The current goal of diabetes therapy is to reduce time-averaged mean levels of glycemia,
measured as HbA1c, to prevent diabetic complications. However, HbA1c only explains< …

Background We recently showed that enzymes of the TET family convert 5-mC to 5-
hydroxymethylcytosine (5-hmC) in DNA. 5-hmC is present at high levels in embryonic stem …

Protein lysine deacetylases have a pivotal role in numerous biological processes and can
be divided into the Rpd3/Hda1 and sirtuin families, each having members in diverse …

Abstract DNA methyltransferase (cytosine-5) 1 (Dnmt1) is the principal enzyme responsible
for maintenance of CpG methylation and is essential for the regulation of gene expression …

Human cancer cell lines are an integral part of drug discovery practices. However, modeling
the complexity of cancer utilizing these cell lines on standard plastic substrata, does not …

INTRODUCTION Technologies that enable the longitudinal tracking and recording of
molecular events into genomic DNA would be useful for the detailed monitoring of cellular …