Activity-dependent plasticity of vertebrate neurons allows the brain to respond to its
environment. During brain development, both spontaneous and sensory-driven neural …

The Dnmt3a DNA methyltransferase contains in its N-terminal part a PWWP domain that is
involved in chromatin targeting. Here, we have investigated the interaction of the PWWP …

Cytosine methylation, a common form of DNA modification that antagonizes transcription, is
found at transposons and repeats in vertebrates, plants and fungi. Here we have mapped …

Highlights•Identified as a master regulator of neuronal genes in embryogenesis, REST is a
common theme in neurodegeneration.•Whereas bioinformatics predicts∼ 2000 REST …

Several studies have recently identified strong epigenetic signals related to tobacco
smoking. However, an aspect that did not receive much attention is the evolution of …

DNA methylation regulates many cellular processes, including embryonic development,
transcription, chromatin structure, X-chromosome inactivation, genomic imprinting and …

DNA methylation represents a form of genome annotation that mediates gene repression by
serving as a maintainable mark that can be used to reconstruct silent chromatin following …

Chromatin is a highly regulated nucleoprotein complex through which genetic material is
structured and maneuvered to elicit cellular processes, including transcription, cell division …

Epigenetics involves the heritable changes in patterns of gene expression determined by
developmental and abiotic stresses, ie, drought, cold, salinity, trace metals, and heat. Gene …

The prevalence of obesity and associated diseases has reached pandemic levels. Obesity is
often associated with overnutrition and a sedentary lifestyle, but clearly other factors also …