DNA methylation represents a form of genome annotation that mediates gene repression by
serving as a maintainable mark that can be used to reconstruct silent chromatin following …

Chromatin is a highly regulated nucleoprotein complex through which genetic material is
structured and maneuvered to elicit cellular processes, including transcription, cell division …

Human cancer cell lines are an integral part of drug discovery practices. However, modeling
the complexity of cancer utilizing these cell lines on standard plastic substrata, does not …

Background Enhanced glucocorticoid receptor (GR) sensitivity is present in people with
posttraumatic stress disorder (PTSD), but the molecular mechanisms of GR sensitivity are …

Suicide ranks among the leading causes of death around the world and takes a heavy
emotional and public health toll on most societies. Both distal and proximal factors contribute …

Functionally exhausted T cells have high expression of the PD-1 inhibitory receptor, and
therapies that block PD-1 signaling show promise for resolving chronic viral infections and …

The importance of eukaryotic DNA methylation [5-methylcytosine (5mC)] in transcriptional
regulation and development was first suggested almost 40 years ago. However, the …

Memory formation and storage require long-lasting changes in memory-related neuronal
circuits. Recent evidence indicates that DNA methylation may serve as a contributing …

Various chemical modifications on histones and regions of associated DNA play crucial
roles in genome management by binding specific factors that, in turn, serve to alter the …

Epigenetics refers to stable alterations in gene expression with no underlying modifications
in the genetic sequence and is best exemplified by differentiation, in which multiple cell …