Mammalian gene silencing is established through methylation of histones and DNA,
although the order in which these modifications occur remains contentious. Using the …

The present system of radiation protection assumes that exposure at low doses and/or low
dose-rates leads to health risks linearly related to the dose. They are evaluated by a …

Mutations or duplications in MECP2 cause Rett and Rett-like syndromes,
neurodevelopmental disorders characterized by mental retardation, motor dysfunction, and …

Prenatal adverse environments, such as maternal stress, toxicological exposures, and viral
infections, can disrupt normal brain development and contribute to neurodevelopmental …

Like many eukaryotes, bacteria make widespread use of postreplicative DNA methylation for
the epigenetic control of DNA-protein interactions. Unlike eukaryotes, however, bacteria use …

BACKGROUND: Childhood abuse alters hypothalamic-pituitary-adrenal (HPA) function and
increases the risk of suicide. Hippocampal glucocorticoid receptor (GR) activation regulates …

DNA and histone methylation are linked and subjected to mitotic inheritance in mammals.
Yet how methylation is propagated and maintained between successive cell divisions is not …

Preserving genome function and stability are paramount for ensuring cellular homeostasis,
an imbalance in which can promote diseases including cancer. In the presence of DNA …

Fortification of food with folic acid to reduce the number of neural tube defects was
introduced 10 y ago in North America. Many countries are considering whether to adopt this …

Processes that regulate gene transcription are directly under the influence of the genome
organization. The epigenome contains additional information that is not brought by DNA …