Inhibitors of protein methyltransferases and demethylases
Post-translational modifications of histones by protein methyltransferases (PMTs) and
histone demethylases (KDMs) play an important role in the regulation of gene expression …
histone demethylases (KDMs) play an important role in the regulation of gene expression …
The current status of latency reversing agents for HIV-1 remission
A Rodari, G Darcis, CM Van Lint - Annual review of virology, 2021 - annualreviews.org
Combinatory antiretroviral therapy (cART) reduces human immunodeficiency virus type 1
(HIV-1) replication but is not curative because cART interruption almost invariably leads to a …
(HIV-1) replication but is not curative because cART interruption almost invariably leads to a …
Proliferation of cells with HIV integrated into cancer genes contributes to persistent infection
TA Wagner, S McLaughlin, K Garg, CYK Cheung… - Science, 2014 - science.org
Antiretroviral treatment (ART) of HIV infection suppresses viral replication. Yet if ART is
stopped, virus reemerges because of the persistence of infected cells. We evaluated the …
stopped, virus reemerges because of the persistence of infected cells. We evaluated the …
Current status of latency reversing agents facing the heterogeneity of HIV-1 cellular and tissue reservoirs
One of the most explored therapeutic approaches aimed at eradicating HIV-1 reservoirs is
the “shock and kill” strategy which is based on HIV-1 reactivation in latently-infected cells …
the “shock and kill” strategy which is based on HIV-1 reactivation in latently-infected cells …
HIV “shock and kill” therapy: In need of revision
The implementation of antiretroviral therapy 23 years ago has rendered HIV infection
clinically manageable. However, the disease remains incurable, since it establishes latent …
clinically manageable. However, the disease remains incurable, since it establishes latent …
Role of histone post-translational modifications in inflammatory diseases
Y Lin, T Qiu, G Wei, Y Que, W Wang, Y Kong… - Frontiers in …, 2022 - frontiersin.org
Inflammation is a defensive reaction for external stimuli to the human body and generally
accompanied by immune responses, which is associated with multiple diseases such as …
accompanied by immune responses, which is associated with multiple diseases such as …
A chemical probe selectively inhibits G9a and GLP methyltransferase activity in cells
Protein lysine methyltransferases G9a and GLP modulate the transcriptional repression of a
variety of genes via dimethylation of Lys9 on histone H3 (H3K9me2) as well as …
variety of genes via dimethylation of Lys9 on histone H3 (H3K9me2) as well as …
The mTOR complex controls HIV latency
Summary A population of CD4 T lymphocytes harboring latent HIV genomes can persist in
patients on antiretroviral therapy, posing a barrier to HIV eradication. To examine cellular …
patients on antiretroviral therapy, posing a barrier to HIV eradication. To examine cellular …
Barriers to a cure for HIV: new ways to target and eradicate HIV-1 reservoirs
C Katlama, SG Deeks, B Autran, J Martinez-Picado… - The Lancet, 2013 - thelancet.com
Antiretroviral therapy for HIV infection needs lifelong access and strict adherence to
regimens that are both expensive and associated with toxic effects. A curative intervention …
regimens that are both expensive and associated with toxic effects. A curative intervention …
Nuclear landscape of HIV-1 infection and integration
M Lusic, RF Siliciano - Nature Reviews Microbiology, 2017 - nature.com
To complete its life cycle, HIV-1 enters the nucleus of the host cell as reverse-transcribed
viral DNA. The nucleus is a complex environment, in which chromatin is organized to …
viral DNA. The nucleus is a complex environment, in which chromatin is organized to …