Enzymes involved in the bioconversion of ester-based prodrugs

BM Liederer, RT Borchardt - Journal of pharmaceutical sciences, 2006 - Elsevier
Enzymes are essential for the activation of many prodrugs. In this review, the most important
enzymes (eg, paraoxonase, carboxylesterase, acetylcholinesterase, cholinesterase) …

Applications of carboxylesterase activity in environmental monitoring and toxicity identification evaluations (TIEs)

CE Wheelock, BM Phillips, BS Anderson… - Reviews of …, 2008 - Springer
The purpose of this review is to examine uses of carboxylesterase activity in environmental
monitoring with a specific emphasis on pyrethroid insecticides. The chapter begins with an …

The juvenile hormones

WG Goodman, M Cusson - Insect endocrinology, 2012 - Elsevier
Publisher Summary This chapter discusses the juvenile hormones (JH). The JH, a family of
acyclic sesquiterpenoids, are essential to insect development and reproduction. This …

Accumulation and Endocrine Disrupting Effects of the Flame Retardant Mixture Firemaster® 550 in Rats: An Exploratory Assessment

HB Patisaul, SC Roberts, N Mabrey… - … of biochemical and …, 2013 - Wiley Online Library
ABSTRACT Firemaster® 550 (FM 550), a fire‐retardant mixture used in foam‐based
products, was recently identified as a common contaminant in household dust. The chemical …

Identification and characterization of novel benzil (diphenylethane-1, 2-dione) analogues as inhibitors of mammalian carboxylesterases

RM Wadkins, JL Hyatt, X Wei, KJP Yoon… - Journal of medicinal …, 2005 - ACS Publications
Carboxylesterases (CE) are ubiquitous enzymes responsible for the metabolism of
xenobiotics. Because the structural and amino acid homology among esterases of different …

Carboxylesterase inhibitors

MJ Hatfield, PM Potter - Expert opinion on therapeutic patents, 2011 - Taylor & Francis
Introduction: Carboxylesterases play major roles in the hydrolysis of numerous
therapeutically active compounds. This is, in part, due to the prevalence of the ester moiety …

Carboxylesterases-detoxifying enzymes and targets for drug therapy

PM Potter, RM Wadkins - Current medicinal chemistry, 2006 - ingentaconnect.com
Carboxylesterases (CE) are ubiquitous enzymes responsible for the detoxification of
xenobiotics. Many therapeutically useful drugs are metabolized by these proteins which …

Individual variability in esterase activity and CYP1A levels in Chinook salmon (Oncorhynchus tshawytscha) exposed to esfenvalerate and chlorpyrifos

CE Wheelock, KJ Eder, I Werner, H Huang, PD Jones… - Aquatic Toxicology, 2005 - Elsevier
Acetylcholinesterase (AChE) activity has traditionally been monitored as a biomarker of
organophosphate (OP) and/or carbamate exposure. However, AChE activity may not be the …

Elevated temperatures increase the toxicity of pesticide mixtures to juvenile coho salmon

CA Laetz, DH Baldwin, VR Hebert, JD Stark, NL Scholz - Aquatic toxicology, 2014 - Elsevier
Pesticide mixtures and elevated temperatures are parallel freshwater habitat stressors for
Pacific salmon in the western United States. Certain combinations of organophosphate (OP) …

G3. 5 PAMAM dendrimers enhance transepithelial transport of SN38 while minimizing gastrointestinal toxicity

DS Goldberg, N Vijayalakshmi, PW Swaan… - Journal of controlled …, 2011 - Elsevier
Poly (amido amine)(PAMAM) dendrimers have shown promise in oral drug delivery.
Conjugation of SN38 to PAMAM dendrimers has the potential to improve its oral absorption …