Enzymes involved in the bioconversion of ester-based prodrugs
BM Liederer, RT Borchardt - Journal of pharmaceutical sciences, 2006 - Elsevier
Enzymes are essential for the activation of many prodrugs. In this review, the most important
enzymes (eg, paraoxonase, carboxylesterase, acetylcholinesterase, cholinesterase) …
enzymes (eg, paraoxonase, carboxylesterase, acetylcholinesterase, cholinesterase) …
Applications of carboxylesterase activity in environmental monitoring and toxicity identification evaluations (TIEs)
CE Wheelock, BM Phillips, BS Anderson… - Reviews of …, 2008 - Springer
The purpose of this review is to examine uses of carboxylesterase activity in environmental
monitoring with a specific emphasis on pyrethroid insecticides. The chapter begins with an …
monitoring with a specific emphasis on pyrethroid insecticides. The chapter begins with an …
The juvenile hormones
WG Goodman, M Cusson - Insect endocrinology, 2012 - Elsevier
Publisher Summary This chapter discusses the juvenile hormones (JH). The JH, a family of
acyclic sesquiterpenoids, are essential to insect development and reproduction. This …
acyclic sesquiterpenoids, are essential to insect development and reproduction. This …
Accumulation and Endocrine Disrupting Effects of the Flame Retardant Mixture Firemaster® 550 in Rats: An Exploratory Assessment
HB Patisaul, SC Roberts, N Mabrey… - … of biochemical and …, 2013 - Wiley Online Library
ABSTRACT Firemaster® 550 (FM 550), a fire‐retardant mixture used in foam‐based
products, was recently identified as a common contaminant in household dust. The chemical …
products, was recently identified as a common contaminant in household dust. The chemical …
Identification and characterization of novel benzil (diphenylethane-1, 2-dione) analogues as inhibitors of mammalian carboxylesterases
RM Wadkins, JL Hyatt, X Wei, KJP Yoon… - Journal of medicinal …, 2005 - ACS Publications
Carboxylesterases (CE) are ubiquitous enzymes responsible for the metabolism of
xenobiotics. Because the structural and amino acid homology among esterases of different …
xenobiotics. Because the structural and amino acid homology among esterases of different …
Carboxylesterase inhibitors
MJ Hatfield, PM Potter - Expert opinion on therapeutic patents, 2011 - Taylor & Francis
Introduction: Carboxylesterases play major roles in the hydrolysis of numerous
therapeutically active compounds. This is, in part, due to the prevalence of the ester moiety …
therapeutically active compounds. This is, in part, due to the prevalence of the ester moiety …
Carboxylesterases-detoxifying enzymes and targets for drug therapy
PM Potter, RM Wadkins - Current medicinal chemistry, 2006 - ingentaconnect.com
Carboxylesterases (CE) are ubiquitous enzymes responsible for the detoxification of
xenobiotics. Many therapeutically useful drugs are metabolized by these proteins which …
xenobiotics. Many therapeutically useful drugs are metabolized by these proteins which …
Individual variability in esterase activity and CYP1A levels in Chinook salmon (Oncorhynchus tshawytscha) exposed to esfenvalerate and chlorpyrifos
CE Wheelock, KJ Eder, I Werner, H Huang, PD Jones… - Aquatic Toxicology, 2005 - Elsevier
Acetylcholinesterase (AChE) activity has traditionally been monitored as a biomarker of
organophosphate (OP) and/or carbamate exposure. However, AChE activity may not be the …
organophosphate (OP) and/or carbamate exposure. However, AChE activity may not be the …
Elevated temperatures increase the toxicity of pesticide mixtures to juvenile coho salmon
Pesticide mixtures and elevated temperatures are parallel freshwater habitat stressors for
Pacific salmon in the western United States. Certain combinations of organophosphate (OP) …
Pacific salmon in the western United States. Certain combinations of organophosphate (OP) …
G3. 5 PAMAM dendrimers enhance transepithelial transport of SN38 while minimizing gastrointestinal toxicity
DS Goldberg, N Vijayalakshmi, PW Swaan… - Journal of controlled …, 2011 - Elsevier
Poly (amido amine)(PAMAM) dendrimers have shown promise in oral drug delivery.
Conjugation of SN38 to PAMAM dendrimers has the potential to improve its oral absorption …
Conjugation of SN38 to PAMAM dendrimers has the potential to improve its oral absorption …