Obesity is associated with metabolic derangements in multiple tissues, which contribute to
the progression of insulin resistance and the metabolic syndrome. The underlying stimulus …

Muscle atrophy is caused by an imbalance in contractile protein synthesis and degradation
which can be triggered by various conditions including Type 2 Diabetes Mellitus (T2DM) …

Insulin resistance is a hallmark of type 2 diabetes mellitus and is associated with a metabolic
and cardiovascular cluster of disorders (dyslipidaemia, hypertension, obesity [especially …

Obesity is associated with an enhanced inflammatory response that exacerbates insulin
resistance and contributes to diabetes, atherosclerosis, and cardiovascular disease. One …

Obesity increases the risk for a number of diseases including cardiovascular diseases and
type 2 diabetes. Excess saturated fatty acids (SFAs) in obesity play a significant role in …

OBJECTIVE Individuals with type 2 diabetes have a myriad of metabolic aberrations
including increased inflammation, increasing their cardiovascular risk. Toll-like receptors …

Nearly all stress stimuli (eg, inflammatory cytokines, glucocorticoids, chemotherapeutics,
etc.) induce sphingolipid synthesis, leading to the accumulation of ceramides and ceramide …

Obesity is accompanied by the activation of low-grade inflammatory activity in metabolically
relevant tissues. Studies have shown that obesity-associated insulin resistance results from …

Inflammation contributes to the tubulointerstitial lesions of diabetic nephropathy. Toll-like
receptors (TLRs) modulate immune responses and inflammatory diseases, but their role in …

As dietary exposure to fructose has increased over the past 40 years, there is growing
concern that high fructose consumption in humans may be in part responsible for the rising …