Metabolic endotoxemia with obesity: Is it real and is it relevant?
NE Boutagy, RP McMillan, MI Frisard, MW Hulver - Biochimie, 2016 - Elsevier
Obesity is associated with metabolic derangements in multiple tissues, which contribute to
the progression of insulin resistance and the metabolic syndrome. The underlying stimulus …
the progression of insulin resistance and the metabolic syndrome. The underlying stimulus …
[HTML][HTML] Muscle atrophy in patients with Type 2 Diabetes Mellitus: roles of inflammatory pathways, physical activity and exercise
Muscle atrophy is caused by an imbalance in contractile protein synthesis and degradation
which can be triggered by various conditions including Type 2 Diabetes Mellitus (T2DM) …
which can be triggered by various conditions including Type 2 Diabetes Mellitus (T2DM) …
Insulin resistance, lipotoxicity, type 2 diabetes and atherosclerosis: the missing links. The Claude Bernard Lecture 2009
RA DeFronzo - Diabetologia, 2010 - Springer
Insulin resistance is a hallmark of type 2 diabetes mellitus and is associated with a metabolic
and cardiovascular cluster of disorders (dyslipidaemia, hypertension, obesity [especially …
and cardiovascular cluster of disorders (dyslipidaemia, hypertension, obesity [especially …
Lipid-induced insulin resistance mediated by the proinflammatory receptor TLR4 requires saturated fatty acid–induced ceramide biosynthesis in mice
WL Holland, BT Bikman, LP Wang… - The Journal of …, 2011 - Am Soc Clin Investig
Obesity is associated with an enhanced inflammatory response that exacerbates insulin
resistance and contributes to diabetes, atherosclerosis, and cardiovascular disease. One …
resistance and contributes to diabetes, atherosclerosis, and cardiovascular disease. One …
Saturated palmitic acid induces myocardial inflammatory injuries through direct binding to TLR4 accessory protein MD2
Y Wang, Y Qian, Q Fang, P Zhong, W Li, L Wang… - Nature …, 2017 - nature.com
Obesity increases the risk for a number of diseases including cardiovascular diseases and
type 2 diabetes. Excess saturated fatty acids (SFAs) in obesity play a significant role in …
type 2 diabetes. Excess saturated fatty acids (SFAs) in obesity play a significant role in …
Increased toll-like receptor (TLR) activation and TLR ligands in recently diagnosed type 2 diabetic subjects
OBJECTIVE Individuals with type 2 diabetes have a myriad of metabolic aberrations
including increased inflammation, increasing their cardiovascular risk. Toll-like receptors …
including increased inflammation, increasing their cardiovascular risk. Toll-like receptors …
Ceramides as modulators of cellular and whole-body metabolism
BT Bikman, SA Summers - The Journal of clinical …, 2011 - Am Soc Clin Investig
Nearly all stress stimuli (eg, inflammatory cytokines, glucocorticoids, chemotherapeutics,
etc.) induce sphingolipid synthesis, leading to the accumulation of ceramides and ceramide …
etc.) induce sphingolipid synthesis, leading to the accumulation of ceramides and ceramide …
TLR4 at the crossroads of nutrients, gut microbiota, and metabolic inflammation
Obesity is accompanied by the activation of low-grade inflammatory activity in metabolically
relevant tissues. Studies have shown that obesity-associated insulin resistance results from …
relevant tissues. Studies have shown that obesity-associated insulin resistance results from …
Toll-like receptor 4 promotes tubular inflammation in diabetic nephropathy
M Lin, WH Yiu, HJ Wu, LYY Chan… - Journal of the …, 2012 - journals.lww.com
Inflammation contributes to the tubulointerstitial lesions of diabetic nephropathy. Toll-like
receptors (TLRs) modulate immune responses and inflammatory diseases, but their role in …
receptors (TLRs) modulate immune responses and inflammatory diseases, but their role in …
[HTML][HTML] Fructose: a highly lipogenic nutrient implicated in insulin resistance, hepatic steatosis, and the metabolic syndrome
MJ Dekker, Q Su, C Baker… - American Journal of …, 2010 - journals.physiology.org
As dietary exposure to fructose has increased over the past 40 years, there is growing
concern that high fructose consumption in humans may be in part responsible for the rising …
concern that high fructose consumption in humans may be in part responsible for the rising …