The multiple roles of transcription/repair factor TFIIH
JQ Svejstrup, P Vichi, JM Egly - Trends in biochemical sciences, 1996 - cell.com
TFIIH is by far the most complex of the basal RNA polymerase II transcription factors. It is a
protein kinase, a bi-directional DNA helicase and is essential for both transcription and …
protein kinase, a bi-directional DNA helicase and is essential for both transcription and …
Variation in DNA repair is a factor in cancer susceptibility: a paradigm for the promises and perils of individual and population risk estimation?
HW Mohrenweiser, IM Jones - Mutation Research/Fundamental and …, 1998 - Elsevier
The repair of DNA damage protects the genome of the cell from the insults of cancer causing
agents. This was originally demonstrated in individuals with the rare genetic disease …
agents. This was originally demonstrated in individuals with the rare genetic disease …
Nonconservative amino acid substitution variants exist at polymorphic frequency in DNA repair genes in healthy humans
MR Shen, IM Jones, H Mohrenweiser - Cancer research, 1998 - AACR
The removal or repair of DNA damage has a key role in protecting the genome of the cell
from the insults of cancer-causing agents. This was originally demonstrated in individuals …
from the insults of cancer-causing agents. This was originally demonstrated in individuals …
Expression of the p48 xeroderma pigmentosum gene is p53-dependent and is involved in global genomic repair
In human cells, efficient global genomic repair of DNA damage induced by ultraviolet
radiation requires the p53 tumor suppressor, but the mechanism has been unclear. The p48 …
radiation requires the p53 tumor suppressor, but the mechanism has been unclear. The p48 …
XRCC1 , XRCC3 , XPD gene polymorphisms, smoking and 32 P-DNA adducts in a sample of healthy subjects
DNA repair genes have an important role in protecting individuals from cancer-causing
agents. Polymorphisms in several DNA repair genes have been identified and individuals …
agents. Polymorphisms in several DNA repair genes have been identified and individuals …
In vitro repair of oxidative DNA damage by human nucleotide excision repair system: Possible explanation for neurodegeneration in Xeroderma pigmentosum …
JT Reardon, T Bessho, HC Kung… - Proceedings of the …, 1997 - National Acad Sciences
Xeroderma pigmentosum (XP) patients fail to remove pyrimidine dimers caused by sunlight
and, as a consequence, develop multiple cancers in areas exposed to light. The second …
and, as a consequence, develop multiple cancers in areas exposed to light. The second …
A Variant within the DNA Repair Gene XRCC3 Is Associated with the Development of Melanoma Skin Cancer
SL Winsey, NA Haldar, HP Marsh, M Bunce… - Cancer Research, 2000 - AACR
Exposure to UV radiation is a major risk factor for the development of malignant melanoma.
DNA damage caused by UV radiation is thought to play a major role in carcinogenesis …
DNA damage caused by UV radiation is thought to play a major role in carcinogenesis …
[HTML][HTML] rqh1+, a fission yeast gene related to the Bloom's and Werner's syndrome genes, is required for reversible S phase arrest
E Stewart, CR Chapman, F Al‐Khodairy… - The EMBO …, 1997 - embopress.org
In eukaryotic cells, S phase can be reversibly arrested by drugs that inhibit DNA synthesis or
DNA damage. Here we show that recovery from such treatments is under genetic control …
DNA damage. Here we show that recovery from such treatments is under genetic control …
5-Methylcytosine DNA demethylation: more than losing a methyl group
DM Franchini, KM Schmitz… - Annual review of …, 2012 - annualreviews.org
Demethylation of 5-methylcytosine in DNA is integral to the maintenance of an intact
epigenome. The balance between the presence or absence of 5-methylcytosine determines …
epigenome. The balance between the presence or absence of 5-methylcytosine determines …
Genetic variability in susceptibility and response to toxicants
MC Miller III, HW Mohrenweiser, DA Bell - Toxicology letters, 2001 - Elsevier
Everyone has a unique combination of polymorphic traits that modify susceptibility and
response to drugs, chemicals and carcinogenic exposures. The metabolism of exogenous …
response to drugs, chemicals and carcinogenic exposures. The metabolism of exogenous …