Purpose Inadequate piperacillin (PIP) exposure in intensive care unit (ICU) patients
threatens therapeutic success. Model-informed precision dosing (MIPD) might be promising …

The main recent change observed in the field of critical patient infection has been universal
awareness of the need to make better use of antimicrobials, especially for the most serious …

Cefepime exhibits highly variable pharmacokinetics in critically ill patients. The purpose of
this study was to develop and qualify a population pharmacokinetic model for use in the …

Purpose Early recognition and effective treatment of sepsis improves outcomes in critically ill
patients. However, antibiotic exposures are frequently suboptimal in the intensive care unit …

Model-informed precision dosing (MIPD) might be used to optimize antibiotic treatment.
Procalcitonin (PCT) is a biomarker for severity of infection and response to antibiotic …

Patients treated with ECMO are at great risk of nosocomial infections, and around 10% of
isolates are gram-positive pathogens. Linezolid (LZD) is effective in the treatment of these …

We would like to thank Liebchen et al.[1] for their comments on our article.[2] Furthermore,
we would like to thank Cotta and colleagues, who wrote a relevant editorial regarding the …

Infections in critically ill patients are associated with significant morbidity and mortality
whereby prompt administration of antimicrobials is crucial to help optimise treatment …