Amyotrophic lateral sclerosis is a fatal CNS neurodegenerative disease. Despite intensive
research, current management of amyotrophic lateral sclerosis remains suboptimal from …

The prevailing motor neuron-centric view of amyotrophic lateral sclerosis (ALS)
pathogenesis could be an important factor in the failure to identify disease-modifying therapy …

The diagnosis of amyotrophic lateral sclerosis can be challenging due to its heterogeneity in
clinical presentation and overlap with other neurological disorders. Diagnosis early in the …

Abstract Amyotrophic Lateral Sclerosis (ALS) is a devastating neurodegenerative disease in
which many processes are detected including (neuro) inflammation. Many drugs have been …

Axon degeneration is an early pathological event in many neurological diseases. The
identification of the nicotinamide adenine dinucleotide (NAD) hydrolase SARM1 as a central …

Background: Neurofilament light chain (NfL) is a validated biofluid marker of neuroaxonal
damage with great potential for monitoring patients with neurodegenerative diseases. We …

Background The survival time of amyotrophic lateral sclerosis (ALS) is greatly variable and
protective or risk effects of the potential survival predictors are controversial. Thus, we aim to …

Background Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder that is
accompanied by muscle weakness and muscle atrophy, typically resulting in death within 3 …

The noncoding genome is substantially larger than the protein-coding genome but has been
largely unexplored by genetic association studies. Here, we performed region-based rare …

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by
loss of upper and lower motor neurons, resulting in progressive weakness of all voluntary …