Cellular and molecular pathobiology of heart failure with preserved ejection fraction
Heart failure with preserved ejection fraction (HFpEF) affects half of all patients with heart
failure worldwide, is increasing in prevalence, confers substantial morbidity and mortality …
failure worldwide, is increasing in prevalence, confers substantial morbidity and mortality …
New concepts in diastolic dysfunction and diastolic heart failure: Part II: causal mechanisms and treatment
MR Zile, DL Brutsaert - Circulation, 2002 - Am Heart Assoc
titin extension during diastole is limited and protects the myocardium from being stretched
too far beyond resting length. In experimental end-stage dilated cardiomyopathy, titin …
too far beyond resting length. In experimental end-stage dilated cardiomyopathy, titin …
Rat models of hypertension, cardiac hypertrophy and failure
SA Doggrell, L Brown - Cardiovascular research, 1998 - academic.oup.com
1. Introduction markedly increases with age [1] yet most models of hypertension and heart
failure only use young adult rats. Animals have been used by humans for centuries to …
failure only use young adult rats. Animals have been used by humans for centuries to …
The heart in hypertension
ED Frohlich, C Apstein, AV Chobanian… - … England Journal of …, 1992 - Mass Medical Soc
HYPERTENSIVE heart disease can be defined as the response of the heart to the afterload
imposed on the left ventricle by the progressively increasing arterial pressure and total …
imposed on the left ventricle by the progressively increasing arterial pressure and total …
Bone marrow-derived fibroblast precursors mediate ischemic cardiomyopathy in mice
SB Haudek, Y Xia, P Huebener… - Proceedings of the …, 2006 - National Acad Sciences
We previously described a mouse model of fibrotic ischemia/reperfusion cardiomyopathy
(I/RC) arising from daily, brief coronary occlusion. One characteristic of I/RC was the …
(I/RC) arising from daily, brief coronary occlusion. One characteristic of I/RC was the …
Evidence for abnormal left ventricular structure and function in normotensive individuals with familial hyperaldosteronism type I
M Stowasser, J Sharman, R Leano… - The Journal of …, 2005 - academic.oup.com
Objectives: To explore whether aldosterone excess can induce adverse cardiovascular
effects independently of effects on blood pressure (BP), we sought evidence of disturbed …
effects independently of effects on blood pressure (BP), we sought evidence of disturbed …
Influence of collagen network on left ventricular systolic and diastolic function in aortic valve disease
B Villari, SE Campbell, OM Hess, G Mall… - Journal of the American …, 1993 - Elsevier
Objectives. The purpose of this study was to evaluate left ventricular structure-function
interplay in aortic valve disease. Background. An increase in myocardial fibrosis has been …
interplay in aortic valve disease. Background. An increase in myocardial fibrosis has been …
Hemodynamic and cellular response feedback in calcific aortic valve disease
ST Gould, S Srigunapalan, CA Simmons… - Circulation …, 2013 - Am Heart Assoc
This review highlights aspects of calcific aortic valve disease that encompass the entire
range of aortic valve disease progression from initial cellular changes to aortic valve …
range of aortic valve disease progression from initial cellular changes to aortic valve …
Role of extracellular matrix proteins in heart function
V Pelouch, IMC Dixon, L Golfman, RE Beamish… - Molecular and cellular …, 1993 - Springer
The cardiac interstitium is populated by nonmyocyte cell types including transcriptionally
active cardiac fibroblasts and endothelial cells. Since these cells are the source of many …
active cardiac fibroblasts and endothelial cells. Since these cells are the source of many …
Cardiac mast cell-and chymase-mediated matrix metalloproteinase activity and left ventricular remodeling in mitral regurgitation in the dog
JA Stewart Jr, CC Wei, GL Brower, PE Rynders… - Journal of molecular and …, 2003 - Elsevier
The present study tested the hypothesis that cardiac mast cells and chymase are associated
with matrix metalloproteinase (MMP) activation and extracellular matrix (ECM) degradation …
with matrix metalloproteinase (MMP) activation and extracellular matrix (ECM) degradation …