Heart failure with preserved ejection fraction (HFpEF) affects half of all patients with heart
failure worldwide, is increasing in prevalence, confers substantial morbidity and mortality …

titin extension during diastole is limited and protects the myocardium from being stretched
too far beyond resting length. In experimental end-stage dilated cardiomyopathy, titin …

1. Introduction markedly increases with age [1] yet most models of hypertension and heart
failure only use young adult rats. Animals have been used by humans for centuries to …

HYPERTENSIVE heart disease can be defined as the response of the heart to the afterload
imposed on the left ventricle by the progressively increasing arterial pressure and total …

We previously described a mouse model of fibrotic ischemia/reperfusion cardiomyopathy
(I/RC) arising from daily, brief coronary occlusion. One characteristic of I/RC was the …

Objectives: To explore whether aldosterone excess can induce adverse cardiovascular
effects independently of effects on blood pressure (BP), we sought evidence of disturbed …

Objectives. The purpose of this study was to evaluate left ventricular structure-function
interplay in aortic valve disease. Background. An increase in myocardial fibrosis has been …

This review highlights aspects of calcific aortic valve disease that encompass the entire
range of aortic valve disease progression from initial cellular changes to aortic valve …

The cardiac interstitium is populated by nonmyocyte cell types including transcriptionally
active cardiac fibroblasts and endothelial cells. Since these cells are the source of many …

The present study tested the hypothesis that cardiac mast cells and chymase are associated
with matrix metalloproteinase (MMP) activation and extracellular matrix (ECM) degradation …