Biomechanical factors play fundamental roles in the natural history of abdominal aortic
aneurysms (AAAs) and their responses to treatment. Advances during the past two decades …

The stiffness and structural integrity of the arterial wall depends primarily on the organization
of the extracellular matrix and the cells that fashion and maintain this matrix. Fundamental to …

Intraluminal thrombus (ILT) is present in over 75% of all abdominal aortic aneurysms (AAAs)
and probably contributes to the complex biomechanics and pathobiology of these lesions. A …

Aortic mechanical and structural characteristics have profound effects on pathophysiology,
but many aspects of physiologic stress-stretch state and intramural changes due to aging …

There has been a growing awareness over the past decade that stiffening of the aorta, and
its attendant effects on hemodynamics, is both an indicator and initiator of diverse …

Collagen is the most abundant protein in mammals and provides the abdominal aortic
aneurysm (AAA) wall with mechanical strength, stiffness and toughness. Specifically, the …

Aims Elastin is the primary component of elastic fibres in arteries, which contribute
significantly to the structural integrity of the wall. Fibrillin-1 is a microfibrillar glycoprotein that …

Elastic and muscular arteries differ in structure, function, and mechanical properties, and
may adapt differently to aging. We compared the descending thoracic aortas (TA) and the …

Spontaneous dissection of the human thoracic aorta is responsible for significant morbidity
and mortality, yet this devastating biomechanical failure process remains poorly understood …

Central artery stiffness has emerged over the past 15 years as a clinically significant
indicator of cardiovascular function and initiator of disease. Loss of elastic fiber integrity is …