Oligodendrocytes are the myelinating cells of the central nervous system (CNS) that are
generated from oligodendrocyte progenitor cells (OPC). OPC are distributed throughout the …

Sox transcription factors play widespread roles during development; however, their versatile
funtions have a relatively simple basis: the binding of a Sox protein alone to DNA does not …

Genome-wide association studies of neurological diseases have identified thousands of
variants associated with disease phenotypes. However, most of these variants do not alter …

Myelin is a defining feature of the vertebrate nervous system. Variability in the thickness of
the myelin envelope is a structural feature affecting the conduction of neuronal signals …

NG2 cells (also known as polydendrocytes) are a population of CNS cells that are distinct
from neurons, mature oligodendrocytes, astrocytes and microglia. They can be identified by …

In the peripheral nervous system, Schwann cells are glial cells that are in intimate contact
with axons throughout development. Schwann cells generate the insulating myelin sheath …

Oligodendrocytes produce myelin, an insulating sheath required for the saltatory conduction
of electrical impulses along axons. Oligodendrocyte loss results in demyelination, which …

The transcriptional control of CNS myelin gene expression is poorly understood. Here we
identify gene model 98, which we have named myelin gene regulatory factor (MRF), as a …

The molecular mechanisms that determine glial cell fate in the vertebrate nervous system
have not been elucidated. Peripheral glial cells differentiate from pluripotent neural crest …

Sox proteins belong to the HMG box superfamily of DNA-binding proteins and are found
throughout the animal kingdom. They are involved in the regulation of such diverse …