Esophageal squamous cell carcinoma (ESCC) is one of the most common human
malignancies worldwide and is associated with high morbidity and mortality. More than 70 …

Background Sepsis is characterised by dysregulated, life-threatening immune responses,
which are thought to be driven by cytokines such as interleukin 6 (IL-6). Genetic variants in …

Neutrophils are the most abundant immune cell in the circulation of human and act as
gatekeepers to discard foreign elements that have entered the body. They are essential in …

Acute and chronic pancreatitis, the latter associated with fibrosis, are multifactorial
inflammatory disorders and leading causes of gastrointestinal disease-related …

The Janus kinase (JAK)–STAT signaling pathway is relevant in both Takayasu and giant cell
arteritis (GCA), and the use of JAK inhibitors (JAKi) in arthritis, psoriasis, and inflammatory …

Aim Interleukin 6 (IL-6) is considered to play a role in the dysbiotic host response in the
development of periodontitis. While the inhibition of the IL-6 receptor using monoclonal …

Abstract Leucine-rich α-2-glycoprotein 1 (LRG1) is a secreted glycoprotein that under
physiological conditions is produced predominantly by the liver. In disease, its local …

The signal transducer and activator of transcription (STAT) is a family of intracellular
cytoplasmic transcription factors involved in many biological functions in mammalian signal …

The pathogenesis of IgA nephropathy (IgAN) is still unknown, but reportedly, interleukin 6 (IL-
6) is involved in this process. However, its role in damaging glomerular endothelial cells is …

Abstract Interleukin-6 (IL-6) is a highly pleiotropic glycoprotein factor that can modulate
innate and adaptive immunity as well as various aspects of metabolism, including glycolysis …