Cytochrome c in cancer therapy and prognosis

J Pessoa - Bioscience Reports, 2022 - portlandpress.com
Cytochrome c (cyt c) is an electron transporter of the mitochondrial respiratory chain. Upon
permeabilization of the mitochondrial outer membrane, cyt c is released into the cytoplasm …

Analysis and characterization of coordination compounds by resonance Raman spectroscopy

M Waechtler, J Guthmuller, L Gonzalez… - Coordination Chemistry …, 2012 - Elsevier
Resonance Raman spectroscopy has become a powerful tool to study excited-state
geometries, excited-state charge distributions and photoinduced reaction dynamics in …

Mitochondria and nuclei dual-targeted heterogeneous hydroxyapatite nanoparticles for enhancing therapeutic efficacy of doxorubicin

H Xiong, S Du, J Ni, J Zhou, J Yao - Biomaterials, 2016 - Elsevier
Dual-targeted nanoparticles have been increasingly used to realize greater anti-proliferation
effect by attacking double key sites of tumor cells. In order to retain nuclei inhibition effect …

Cardiolipin signaling mechanisms: collapse of asymmetry and oxidation

VE Kagan, YY Tyurina, VA Tyurin… - Antioxidants & redox …, 2015 - liebertpub.com
Significance: An ancient anionic phospholipid, cardiolipin (CL), ubiquitously present in
prokaryotic and eukaryotic membranes, is essential for several structural and functional …

Genistein suppresses the mitochondrial apoptotic pathway in hippocampal neurons in rats with Alzheimer's disease

Y Wang, B Cai, J Shao, T Wang, R Cai… - Neural regeneration …, 2016 - journals.lww.com
Genistein is effective against amyloid-β toxicity, but the underlying mechanisms are unclear.
We hypothesized that genistein may protect neurons by inhibiting the mitochondrial …

Characterization of Intramolecular Interactions of Cytochrome c Using Hydrogen–Deuterium Exchange-Trapped Ion Mobility Spectrometry–Mass Spectrometry and …

JC Molano-Arevalo, K Jeanne Dit Fouque… - Analytical …, 2017 - ACS Publications
Globular proteins, such as cytochrome c (cyt c), display an organized native conformation,
maintained by a hydrogen bond interaction network. In the present work, the structural …

Primary tumor and pre-metastatic niches co-targeting “peptides-lego” hybrid hydroxyapatite nanoparticles for metastatic breast cancer treatment

H Xiong, S Du, P Zhang, Z Jiang, J Zhou, J Yao - Biomaterials science, 2018 - pubs.rsc.org
Both tumor metastasis resisting therapy (TMRT) and tumor metastasis targeting therapy
(TMTT) attempt to improve tumor metastasis treatment, but they are limited by dynamic …

Time-resolved diffusion method to detect and reveal protein reactions leading to their functions

M Terazima - Bulletin of the Chemical Society of Japan, 2023 - academic.oup.com
Proteins are unique natural macromolecules with high selectivity and efficiency for their
functions. Understanding the chemical reaction mechanisms of proteins has long been an …

Mitochondria and nuclei dual-targeted hollow carbon nanospheres for cancer chemophotodynamic synergistic therapy

R Xie, S Lian, H Peng, C OuYang, S Li… - Molecular …, 2019 - ACS Publications
Dual-targeted nanoparticles are gaining increasing importance as a more effective
anticancer strategy by attacking double key sites of tumor cells, especially in …

Electric-Field Control of the pH-Dependent Redox Process of Cytochrome c Immobilized on a Gold Electrode

B Jin, GX Wang, D Millo, P Hildebrandt… - The Journal of Physical …, 2012 - ACS Publications
The pH-dependent redox processes of cytochrome c (cyt c) immobilized on a gold electrode
that was coated with a self-assembled monolayer (SAM) of mercaptounadecanoic acid …