[HTML][HTML] Role of glial cells in the generation of sex differences in neurodegenerative diseases and brain aging

JA Chowen, LM Garcia-Segura - Mechanisms of Ageing and Development, 2021 - Elsevier
Diseases and aging-associated alterations of the nervous system often show sex-specific
characteristics. Glial cells play a major role in the endogenous homeostatic response of …

Sex differences in cognition across aging

BH Lee, JE Richard, RG de Leon, S Yagi… - Sex Differences in Brain …, 2022 - Springer
Sex and gender differences are seen in cognitive disturbances in a variety of neurological
and psychiatry diseases. Men are more likely to have cognitive symptoms in schizophrenia …

Menopause hormone therapy significantly alters pathophysiological biomarkers of Alzheimer's disease

H Depypere, A Vergallo, P Lemercier… - Alzheimer's & …, 2023 - Wiley Online Library
Introduction This increasing body of literature indicates that menopause hormonal
replacement therapy (MHT) may substantially mitigate the risk of developing late‐life …

Relation between sex, menopause, and white matter hyperintensities: the Rhineland study

V Lohner, G Pehlivan, G Sanroma, A Miloschewski… - Neurology, 2022 - AAN Enterprises
Background and Objectives Mounting evidence implies that there are sex differences in
white matter hyperintensity (WMH) burden in older people. Questions remain regarding …

New Horizons: the value of UK Biobank to research on endocrine and metabolic disorders

J Bešević, B Lacey, M Conroy… - The Journal of …, 2022 - academic.oup.com
UK Biobank is an intensively characterized prospective study of 500 000 men and women,
aged 40 to 69 years when recruited, between 2006 and 2010, from the general population of …

[HTML][HTML] Estrogen receptor beta in astrocytes modulates cognitive function in mid-age female mice

N Itoh, Y Itoh, CE Meyer, TT Suen… - Nature …, 2023 - nature.com
Menopause is associated with cognitive deficits and brain atrophy, but the brain region and
cell-specific mechanisms are not fully understood. Here, we identify a sex hormone by age …

Age at natural menopause impacts cerebrovascular reactivity and brain structure

ME Moir, AT Corkery, KA Senese… - American Journal …, 2023 - journals.physiology.org
Menopause is associated with adverse changes in vascular health coinciding with an
increased risk of stroke and vascular cognitive impairment. However, there is significant …

[HTML][HTML] Effects of higher normal blood pressure on brain are detectable before middle-age and differ by sex

K Alateeq, EI Walsh, WP Abhayaratna… - Journal of Clinical …, 2022 - mdpi.com
Background: To quantify the association between blood pressure (BP) across its full range,
brain volumes and white matter lesions (WMLs) while investigating the effects of age, sex …

A review of multi-modal magnetic resonance imaging studies on perimenopausal brain: a hint towards neural heterogeneity

W Lu, Y Sun, H Gao, J Qiu - European Radiology, 2023 - Springer
The population ageing process worldwide is leading to an increasing number of women in
the perimenopausal phase. Many of the perimenopausal symptoms, such as headache …

Beyond sex and gender differences: The case for women's health research

LAM Galea, BH Lee, MN Rajah, G Einstein - Principles of Gender …, 2023 - Elsevier
Women are more likely to be misdiagnosed and suffer the adverse effects of new
therapeutics compared to men. These types of findings were the impetus for mandates from …