With the large-scale use of antibiotics, antibiotic resistant bacteria (ARB) continue to rise,
and antibiotic resistance genes (ARGs) are regarded as emerging environmental pollutants …

The pervasive use of antibiotics in agriculture and animal husbandry has raised a significant
concern—residual antibiotic contamination in food, which contributes to the natural evolution …

The emergence of tet (X) genes has compromised the clinical use of the last-line antibiotic
tigecycline. We identified 322 (1.21%) tet (X) positive samples from 12,829 human …

The emergence of high-level tigecycline resistance mediated by plasmid-borne tet (X) genes
greatly threatens the clinical effectiveness of tigecycline. However, the dissemination pattern …

The rapid dissemination of plasmid-mediated tet (X) genes in Acinetobacter species has
compromised the clinical effectiveness of tigecycline, one of the last-resort antibiotics …

The convergence of bla NDM and tet (X4) in a single strain has been sporadically detected
in diverse pathogens from different sources, causing widespread concerns. However, the …

Objectives Tetracyclines are used in veterinary medicine for livestock. Tigecycline, a
semisynthetic tetracycline derivative, is a last-resort antimicrobial used to treat multidrug …

This study reports an extensively drug resistant Pseudomonas aeruginosa strain PA166-2
which was of chicken origin and carrying bla IMP-45, tet (X6) and tmexCD3-toprJ3 on a …

Mobile tigecycline resistance (MTR) threatens the clinical efficacy of the salvage antibiotic,
tigecycline (TIG) used in treating deadly infections in humans caused by superbugs …

Tigecycline and carbapenems are last-resort antimicrobial agents to treat serious infections
caused by multi-drug resistant bacterial pathogens. However, the co-occurrence of …