Emerging role of RNA acetylation modification ac4C in diseases: current advences and future challenges
J Luo, J Cao, C Chen, H Xie - Biochemical Pharmacology, 2023 - Elsevier
The oldest known highly conserved modification of RNA, N4-acetylcytidine, is widely
distributed from archaea to eukaryotes and acts as a posttranscriptional chemical …
distributed from archaea to eukaryotes and acts as a posttranscriptional chemical …
[HTML][HTML] The role of natural flavonoids as telomerase inhibitors in suppressing Cancer Growth
Cancer is a complex and multifaceted group of diseases characterized by the uncontrolled
growth and spread of abnormal cells. While cancer can be challenging and life-altering …
growth and spread of abnormal cells. While cancer can be challenging and life-altering …
O‐GlcNAcylation Regulates Centrosome Behavior and Cell Polarity to Reduce Pulmonary Fibrosis and Maintain the Epithelial Phenotype
F Yu, S Yang, H Ni, D Heng, X Wu, M Yang… - Advanced …, 2023 - Wiley Online Library
O‐GlcNAcylation functions as a cellular nutrient and stress sensor and participates in almost
all cellular processes. However, it remains unclear whether O‐GlcNAcylation plays a role in …
all cellular processes. However, it remains unclear whether O‐GlcNAcylation plays a role in …
CXCR4 expression is elevated in TNBC patient derived samples and Z-guggulsterone abrogates tumor progression by targeting CXCL12/CXCR4 signaling axis in …
N Gupta, CD Mohan, MK Shanmugam, YY Jung… - Environmental …, 2023 - Elsevier
Environmental factors such as exposure to ionizing radiations, certain environmental
pollutants, and toxic chemicals are considered as risk factors in the development of breast …
pollutants, and toxic chemicals are considered as risk factors in the development of breast …
[HTML][HTML] Trigonelline inhibits tubular epithelial-mesenchymal transformation in diabetic kidney disease via targeting Smad7
M Gong, Y Guo, H Dong, W Wu, F Wu, F Lu - Biomedicine & …, 2023 - Elsevier
Objectives Diabetic kidney disease (DKD) is a prevalent microvascular complication of
diabetes. Inhibiting the epithelial-mesenchymal transition (EMT) of proximal tubule epithelial …
diabetes. Inhibiting the epithelial-mesenchymal transition (EMT) of proximal tubule epithelial …
[HTML][HTML] A nomogram based on collagen signature for predicting the immunoscore in colorectal cancer
W Jiang, X Yu, X Dong, C Long, D Chen… - Frontiers in …, 2023 - frontiersin.org
Objectives The Immunoscore can categorize patients into high-and low-risk groups for
prognostication in colorectal cancer (CRC). Collagen plays an important role in …
prognostication in colorectal cancer (CRC). Collagen plays an important role in …
[HTML][HTML] LAMC2 regulates proliferation, migration, and invasion mediated by the Pl3K/AKT/mTOR pathway in oral
F Shan, L Liang, C Feng, H Xu, Z Wang, W Liu… - Oncology …, 2023 - ncbi.nlm.nih.gov
Background Oral squamous cell carcinoma (OSCC) is a common malignant tumor. Recently,
Laminin Gamma 2 (LAMC2) has been shown to be abnormally expressed in OSCC; …
Laminin Gamma 2 (LAMC2) has been shown to be abnormally expressed in OSCC; …
The strict regulation of HIF-1α by non-coding RNAs: new insight towards proliferation, metastasis, and therapeutic resistance strategies
The hypoxic environment is prominently witnessed in most solid tumors and is associated
with the promotion of cell proliferation, epithelial-mesenchymal transition (EMT) …
with the promotion of cell proliferation, epithelial-mesenchymal transition (EMT) …
[HTML][HTML] ESRP1-driven alternative splicing of CLSTN1 inhibits the metastasis of gastric cancer
C Li, Y Yin, R Tao, Y Lin, T Wang, Q Shen, R Li… - Cell Death …, 2023 - nature.com
Tumor metastasis severely limits the prognosis of gastric cancer patients. RNA-binding
proteins (RBPs) are crucial in tumor metastasis, yet there is limited research into their …
proteins (RBPs) are crucial in tumor metastasis, yet there is limited research into their …
[HTML][HTML] The bidirectional interplay between ncRNAs and methylation modifications in gastrointestinal tumors
M Kong, X Yu, W Guo, R Guo - International Journal of Biological …, 2023 - ncbi.nlm.nih.gov
The aberrant expression of methylation and ncRNAs, two crucial regulators of epigenetic
modifications, has been widely demonstrated in cancer. The complex interplay between …
modifications, has been widely demonstrated in cancer. The complex interplay between …