Regulation of the pro‐inflammatory G protein‐coupled receptor GPR84
S Marsango, G Milligan - British Journal of Pharmacology, 2024 - Wiley Online Library
GPR84 is an understudied rhodopsin‐like class AG protein‐coupled receptor, which is
arousing particular interest from a therapeutic perspective. Not least this reflects that gpr84 …
arousing particular interest from a therapeutic perspective. Not least this reflects that gpr84 …
Biased agonists of GPR84 and insights into biological control
VB Luscombe, P Wang, AJ Russell… - British Journal of …, 2024 - Wiley Online Library
GPR84 was first identified as an open reading frame encoding an orphan Class AG protein
coupled receptor in 2001. Gpr84 mRNA is expressed in a limited number of cell types with …
coupled receptor in 2001. Gpr84 mRNA is expressed in a limited number of cell types with …
The GPR84 molecule is a mediator of a subpopulation of retinal microglia that promote TNF/IL‐1α expression via the rho‐ROCK pathway after optic nerve injury
K Sato, M Ohno‐Oishi, M Yoshida, T Sato, T Aizawa… - Glia, 2023 - Wiley Online Library
Resident microglia are important to maintain homeostasis in the central nervous system,
which includes the retina. The retinal microglia become activated in numerous pathological …
which includes the retina. The retinal microglia become activated in numerous pathological …
Novel methodology to enrich medium-and short-chain fatty acids in milk fat to improve metabolic health
SS Mathiasen, JM Kanta, RP Frydenberg… - Food & Function, 2024 - pubs.rsc.org
Dietary short-and medium-chain fatty acids have been shown to elevate circulating ketone
bodies and confer metabolic health benefits. Cow milk fat contains these lipids in a balanced …
bodies and confer metabolic health benefits. Cow milk fat contains these lipids in a balanced …
A high‐fat diet supplemented with medium‐chain triglycerides ameliorates hepatic steatosis by reducing ceramide and diacylglycerol accumulation in mice
S Mourad, AM Abdualkader, X Li, S Jani… - Experimental …, 2024 - Wiley Online Library
Non‐alcoholic fatty liver disease (NAFLD) is projected to be the most common chronic liver
disease worldwide and is closely linked to obesity, insulin resistance and type 2 diabetes …
disease worldwide and is closely linked to obesity, insulin resistance and type 2 diabetes …
[HTML][HTML] A Medium-Chain Fatty Acid Analogue Prevents Intestinal Failure–Associated Liver Disease in Preterm Yorkshire Piglets
SC Fligor, ST Tsikis, TI Hirsch, A Pan, K Moskowitzova… - Gastroenterology, 2023 - Elsevier
Background & Aims At least 20%–30% of patients with intestinal failure receiving long-term
parenteral nutrition will develop intestinal failure–associated liver disease (IFALD), for which …
parenteral nutrition will develop intestinal failure–associated liver disease (IFALD), for which …
Development of Highly Potent, G-Protein Pathway Biased, Selective, and Orally Bioavailable GPR84 Agonists
P Wang, A Raja, VB Luscombe… - Journal of Medicinal …, 2023 - ACS Publications
Orphan G-protein-coupled receptor 84 (GPR84) is a receptor that has been linked to cancer,
inflammatory, and fibrotic diseases. We have reported DL-175 as a biased agonist at GPR84 …
inflammatory, and fibrotic diseases. We have reported DL-175 as a biased agonist at GPR84 …
[HTML][HTML] Sodium octanoate mediates GPR84-dependent and independent protection against sepsis-induced myocardial dysfunction
Y Lin, W Zhang, X Jiang, C Wu, J Yang, J Tao… - Biomedicine & …, 2024 - Elsevier
Introduction This study aims to evaluate the therapeutic effects of sodium octanoate (SO), a
medium-chain fatty acid salt, on SIMD in a murine model and to explore its underlying …
medium-chain fatty acid salt, on SIMD in a murine model and to explore its underlying …
Ceramides as the molecular link between impaired lipid metabolism, saturated fatty acid intake and insulin resistance: are all saturated fatty acids to be blamed for …
D Sergi, E Zauli, C Celeghini, M Previati… - Nutrition Research …, 2024 - cambridge.org
Type 2 diabetes mellitus (T2DM) is a metabolic disorder that has reached epidemic
proportions worldwide, posing a huge treat on people's health and quality of life. From a …
proportions worldwide, posing a huge treat on people's health and quality of life. From a …
G protein-coupled receptor 84 gene expression is regulated by the ER stress response in the liver.
S Kanemoto - The Journal of Biochemistry, 2024 - academic.oup.com
G protein-coupled receptor 84 (Gpr84) is reportedly activated by medium-chain fatty acids
and is involved in the pathology of liver fibrosis. Inflammatory stimulants, such as …
and is involved in the pathology of liver fibrosis. Inflammatory stimulants, such as …