Proliferating cells regularly experience replication stress caused by spontaneous DNA
damage that results from endogenous reactive oxygen species (ROS), DNA sequences that …

Defective DNA repair is one of the most important features of tumors. BRCA1/2 participates
in homologous recombination repair as a key tumor suppressor gene. BRCA1/2 mutation is …

Simple Summary Synthetic lethality approaches to cancer therapy involves combining
events to cause cancer cell death. Using this strategy, major advances have occurred in the …

Poly ADP-ribose polymerase inhibitor (PARPi) has become an important maintenance
therapy for ovarian cancer after surgery and cytotoxic chemotherapy, which has changed the …

Introduction: Development of Poly (ADP-ribose) polymerase (PARP) inhibitors has been
extensively studied in cancer treatment. Olaparib, the first approved PARP inhibitor, showed …

Abstract Aldehyde dehydrogenase 1A (ALDH1A) isoforms may be a useful target for
overcoming chemotherapy resistance in high-grade serous ovarian cancer (HGSOC) and …

Objective To systematically evaluate the efficacy and safety of olaparib in the treatment of
recurrent platinum-sensitive ovarian cancer. Methods The Cochrane Library, PubMed …

Background Whether neoadjuvant chemotherapy (NAC) followed by interval debulking
surgery (IDS) against primary debulking surgery (PDS) has a differential effect on prognosis …

Objectives: Health Canada's Notice of Compliance with conditions (NOC/c) policy provides
expedited access to promising new therapies for serious conditions. We sought to examine …

Key content Surgical cytoreduction and platinum‐based chemotherapy are the mainstays of
ovarian cancer treatment, but 70% of patients with advanced‐stage disease will relapse …