N-Oxides of heterocyclic compounds are the focus of medical chemistry due to their diverse
biological properties. The high reactivity and tendency to undergo various rearrangements …

The marine environment is an excellent source of molecules that have a wide structural
diversity and a variety of biological activities. Many marine natural products (MNPs) have …

In many types of cancers, pyruvate dehydrogenase kinase (PDK) is abnormally
overexpressed and has become a promising target for cancer therapy. However, few highly …

Pancreatic ductal adenocarcinoma (PDAC) is one of the main aggressive types of cancer,
characterized by late prognosis and drug resistance. Among the main factors sustaining …

A new series of nortopsentin analogs, in which the central imidazole ring of the natural lead
was replaced by a 1, 3, 4-oxadiazole or 1, 3, 4-thiadiazole moiety, was efficiently …

Proliferating cancer cells are characterized by the Warburg effect, a metabolic alteration in
which ATP is generated from cytoplasmic glycolysis instead of oxidative phosphorylation …

Continuing our research into the anticancer properties of acrylonitriles, we present a study
involving the design, synthesis, computational analysis, and biological assessment of novel …

Introduction Prediction of pharmacokinetic (PK) properties is crucial for drug discovery and
development. Machine-learning (ML) models, which use statistical pattern recognition to …

Simple Summary Pancreatic cancer is highly resistant to therapies, and patients do not have
a high 5-year survival rate after diagnosis. The current standard of care therapy for …

Metabolism is reprogrammed in a variety of cancer cells to ensure their rapid proliferation.
Cancer cells prefer to utilize glycolysis to produce energy as well as to provide large …