The nuclear hormone receptor PPARγ promotes adipogenesis and macrophage
differentiation and is a primary pharmacological target in the treatment of type II diabetes …

Background—Tumor necrosis factor-α (TNF-α) and angiotensin II (Ang II) modulate heart
failure in part by provoking the hypertrophic response. Signal transduction pathways of …

Transgenic mice were created with cardiac-specific overexpression of the β2-adrenergic
receptor. This resulted in increased basal myocardial adenylyl cyclase activity, enhanced …

Biomechanical stress is a major stimulus for cardiac hypertrophy and the transition to heart
failure. By generating mice that harbor a ventricular restricted knockout of the gp130 …

We have established a targeted loss-of-function mutation in the RXR alpha gene in the
mouse germ line that results in embryonic lethality between E13. 5 and E16. 5 when bred to …

Nutrition science has evolved considerably in the past decade with new concepts and
discoveries. In response, advanced nutrition courses now encompass material on …

Heart failure continues to be a leading cause of mortality worldwide. A hallmark of this
disease is dilated cardiac hypertrophy, which is accompanied by a reactivation of genes …

In a search for novel factors that induce cardiac myocyte hypertrophy, cardiotrophin-1 (CT-1)
was identified by coupling expression cloning with an embryonic stem cell-based model of …

Although myocardial growth corresponds to an adaptive response to maintain cardiac
contractile function, the cardiac hypertrophy is a condition that occurs in many …

Heat shock treatment induces expression of several heat shock proteins and subsequent
post-ischemic myocardial protection. Correlations exist between the degree of stress used to …