Obsessive-compulsive disorder is a severe and disabling psychiatric disorder that presents
several challenges for neuroscience. Recent advances in its genetic and developmental …

Why has computational psychiatry yet to influence routine clinical practice? One reason may
be that it has neglected context and temporal dynamics in the models of certain mental …

Nearly one billion people worldwide suffer from obsessive–compulsive behaviors,, yet our
mechanistic understanding of these behaviors is incomplete, and effective therapeutics are …

Event-related potentials (ERPs) are direct measures of brain activity that can be leveraged
for clinically meaningful research. They can relate robustly both to continuous measures of …

Metacognition is the ability to reflect on our own cognition and mental states. It is a critical
aspect of human subjective experience and operates across many hierarchical levels of …

Improvements in understanding the neurobiological basis of mental illness have
unfortunately not translated into major advances in treatment. At this point, it is clear that …

Obsessive‐compulsive disorder (OCD) is a complex and heterogeneous disorder that is
associated with high personal and societal costs. Feelings of doubt, worry, and repetitive …

At the group-level, deep brain stimulation leads to significant therapeutic benefit in a
multitude of neurological and neuropsychiatric disorders. At the single-patient level …

Background Error processing and inhibitory control enable the adjustment of behaviors to
meet task demands. Functional magnetic resonance imaging studies report brain activation …

Performance monitoring is an important executive function that allows us to gain insight into
our own behaviour. This remarkable ability relies on the frontal cortex, and its impairment is …