Development and application of brain region–specific organoids for investigating psychiatric disorders

Z Zhang, X Wang, S Park, H Song, GL Ming - Biological psychiatry, 2023 - Elsevier
Human society has been burdened by psychiatric disorders throughout the course of its
history. The emergence and rapid advances of human brain organoid technology provide …

[HTML][HTML] HIV in pregnancy: Mother-to-child transmission, pharmacotherapy, and toxicity

L Cerveny, P Murthi, F Staud - … et Biophysica Acta (BBA)-Molecular Basis of …, 2021 - Elsevier
An estimated 1.3 million pregnant women were living with HIV in 2018. HIV infection is
associated with adverse pregnancy outcomes and all HIV-positive pregnant women …

Early structural brain development in infants exposed to HIV and antiretroviral therapy in utero in a South African birth cohort

CJ Wedderburn, NA Groenewold, A Roos… - African Journal of …, 2022 - journals.lww.com
Introduction: There is a growing population of children who are HIV-exposed and uninfected
(HEU) with the successful expansion of antiretroviral therapy (ART) use in pregnancy …

Contemporary antiretroviral therapy dysregulates iron transport and augments mitochondrial dysfunction in HIV-infected human microglia and neural-lineage cells

H Kaur, P Minchella, D Alvarez-Carbonell… - International Journal of …, 2023 - mdpi.com
HIV-associated cognitive dysfunction during combination antiretroviral therapy (cART)
involves mitochondrial dysfunction, but the impact of contemporary cART on chronic …

Human Brain Organoids as an In Vitro Model System of Viral Infectious Diseases

X Su, P Yue, J Kong, X Xu, Y Zhang, W Cao… - Frontiers in …, 2022 - frontiersin.org
Brain organoids, or brainoids, have shown great promise in the study of central nervous
system (CNS) infection. Modeling Zika virus (ZIKV) infection in brain organoids may help …

HIV-1 integrase strand transfer inhibitors and neurodevelopment

EG Foster, HE Gendelman, AN Bade - Pharmaceuticals, 2022 - mdpi.com
Children born to mothers, with or at risk, of human immunodeficiency virus type-1 (HIV-1)
infection are on the rise due to affordable access of antiretroviral therapy (ART) to pregnant …

Cutting edge strategies for screening of novel anti-HIV drug candidates against HIV infection: a concise overview of cell based assays

SY Gaikwad, P Phatak, A Mukherjee - Heliyon, 2023 - cell.com
Abstract The advent of Highly Active Antiretroviral Therapy has majorly contributed towards
reducing the morbidity and mortality associated with HIV infected people, thus improving the …

Neurodevelopment among children exposed to HIV and uninfected in sub‐Saharan Africa

MA Bulterys, I Njuguna, M Mahy… - Journal of the …, 2023 - Wiley Online Library
Introduction The population of 16 million children exposed to HIV and uninfected (CHEU)
under 15 years of age continues to expand rapidly, and the estimated prevalence of CHEU …

Building the brain from scratch: Engineering region-specific brain organoids from human stem cells to study neural development and disease

F Jacob, JG Schnoll, H Song, G Ming - Current topics in developmental …, 2021 - Elsevier
Human brain development is an intricate process that involves precisely timed coordination
of cell proliferation, fate specification, neuronal differentiation, migration, and integration of …

[图书][B] Pharmacology Research And Textbook 2: HIV-1 Integrase Inhibitors, Coenzyme Q10, and Ferroptosis

AT Mohammadi, R Nouralizadeh, N Naghsh, S Abbasi… - books.google.com
Page 1 Pharmacology Research And Textbook 2 Chapter1: HIV-1 Integrase Inhibitors and
Neurodevelopment Chapter2: Coenzyme Q10 Chapter3: Ferroptosis Author in Chief …