Mitochondrial effects of common cardiovascular medications: the good, the bad and the mixed
AM Bețiu, L Noveanu, IM Hâncu, A Lascu… - International Journal of …, 2022 - mdpi.com
Mitochondria are central organelles in the homeostasis of the cardiovascular system via the
integration of several physiological processes, such as ATP generation via oxidative …
integration of several physiological processes, such as ATP generation via oxidative …
Time to change: A systems pharmacology approach to disentangle mechanisms of drug-induced mitochondrial toxicity
CA Hoogstraten, JJ Lyon, JAM Smeitink… - Pharmacological …, 2023 - ASPET
An increasing number of commonly prescribed drugs are known to interfere with
mitochondrial function, which is associated with almost half of all Food and Drug …
mitochondrial function, which is associated with almost half of all Food and Drug …
Yellow wine polyphenolic compound protects against doxorubicin-induced cardiotoxicity by modulating the composition and metabolic function of the gut microbiota
H Lin, L Meng, Z Sun, S Sun, X Huang, N Lin… - Circulation: Heart …, 2021 - Am Heart Assoc
Background: Dietary polyphenols help to prevent cardiovascular diseases, and interactions
between polyphenols and gut microbiota are known to exist. In this study, we speculated that …
between polyphenols and gut microbiota are known to exist. In this study, we speculated that …
Assessing drug-induced mitochondrial toxicity in cardiomyocytes: implications for preclinical cardiac safety evaluation
X Tang, Z Wang, S Hu, B Zhou - Pharmaceutics, 2022 - mdpi.com
Drug-induced cardiotoxicity not only leads to the attrition of drugs during development, but
also contributes to the high morbidity and mortality rates of cardiovascular diseases …
also contributes to the high morbidity and mortality rates of cardiovascular diseases …
[HTML][HTML] Site-directed deuteration of dronedarone preserves cytochrome P4502J2 activity and mitigates its cardiac adverse effects in canine arrhythmic hearts
AV Karkhanis, G Venkatesan, R Kambayashi… - … Pharmaceutica Sinica B, 2022 - Elsevier
Abstract Cytochrome P4502J2 (CYP2J2) metabolizes arachidonic acid (AA) to
cardioprotective epoxyeicosatrienoic acids (EETs). Dronedarone, an antiarrhythmic drug …
cardioprotective epoxyeicosatrienoic acids (EETs). Dronedarone, an antiarrhythmic drug …
Metabolic activation of drugs by cytochrome P450 enzymes: Biochemical insights into mechanism-based inactivation by fibroblast growth factor receptor inhibitors and …
LWT Tang, ECY Chan - Biochemical Pharmacology, 2022 - Elsevier
Metabolic activation of drugs by cytochrome P450 enzymes (P450) to chemically reactive
electrophiles is commonly regarded as a key molecular-initiating event underpinning …
electrophiles is commonly regarded as a key molecular-initiating event underpinning …
Identification of infigratinib as a potent reversible inhibitor and mechanism-based inactivator of CYP2J2: nascent evidence for a potential in vivo metabolic drug-drug …
Infigratinib (INF) is a fibroblast growth factor receptor inhibitor that was recently United States
Food and Drug Administration-approved for the treatment of advanced or metastatic …
Food and Drug Administration-approved for the treatment of advanced or metastatic …
Cell-permeable succinate rescues mitochondrial respiration in cellular models of amiodarone toxicity
AM Bețiu, I Chamkha, E Gustafsson, E Meijer… - International Journal of …, 2021 - mdpi.com
Amiodarone is a potent antiarrhythmic drug and displays substantial liver toxicity in humans.
It has previously been demonstrated that amiodarone and its metabolite …
It has previously been demonstrated that amiodarone and its metabolite …
[HTML][HTML] Amiodarone but not propafenone impairs bioenergetics and autophagy of human myocardial cells
A Krajčová, V Němcová, M Halačová, P Waldauf… - Toxicology and Applied …, 2023 - Elsevier
Cardiac and extra-cardiac side effects of common antiarrhythmic agents might be related to
drug-induced mitochondrial dysfunction. Supratherapeutic doses of amiodarone have been …
drug-induced mitochondrial dysfunction. Supratherapeutic doses of amiodarone have been …
Inhibition of cytochrome P450 2J2-mediated metabolism of rivaroxaban and arachidonic acid by ibrutinib and osimertinib
Covalent tyrosine kinase inhibitors (TKIs) ibrutinib and osimertinib are associated with
cardiac arrhythmia. The interactions between these TKIs with CYP2J2 that is highly …
cardiac arrhythmia. The interactions between these TKIs with CYP2J2 that is highly …